The SIGnaling Network
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Pathway ID: SIGNOR-EMT

Description: Epithelial-mesenchymal transition (EMT) is a process by which epithelial cells lose their differentiated properties and acquire a mesenchymal phenotype, characterized by increased motility and invasiveness. Although EMT plays a physiological role during embryogenesis and wound healing, it is aberrantly reactivated in cancer, promoting tumor invasion and metastasis. At the molecular level, key signaling pathways, including TGF-β/SMAD, Wnt/β-catenin, Notch, and PI3K/AKT, converge on the transcription factors SNAIL, TWIST, and ZEB, which repress E-cadherin and induce mesenchymal markers such as N-cadherin and vimentin, completing the so-called cadherin switch.

Curated by: Marta Iannuccelli

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