Summary

Name CIT
Full Name Citron Rho-interacting kinase
Synonyms CRIK, Serine/threonine-protein kinase 21 | CRIK, KIAA0949, STK21
Primary ID O14578
Links - -
Type protein
Relations 4
Function Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation MYL9 0.538
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding KIF14 0.714
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CIT 0.714
Publications: 1 Organism: Homo Sapiens