| + |
CIT | up-regulates activity 
phosphorylation
|
MYL9 |
0.542 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260305 |
Ser20 |
KRPQRATsNVFAMFD |
in vitro |
|
| pmid |
sentence |
| 21457715 |
Activation of the catalytic ATPase domain residing in the N‐terminus of the heavy chain relies on the reversible phosphorylation of the associated MLC on Ser19 (monophosphorylation), or in some cases on both Thr18 and Ser19 (diphosphorylation)|We detected Ser19 of MLC as the common phosphorylation site for the catalytic domains of MRCK_/_, ROK_, MLCK and PAK_, but only ROK_ and CRIK are able to phosphorylate both Thr18 and Ser19 residues causing diphosphorylation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260306 |
Thr19 |
KKRPQRAtSNVFAMF |
in vitro |
|
| pmid |
sentence |
| 21457715 |
Activation of the catalytic ATPase domain residing in the N‐terminus of the heavy chain relies on the reversible phosphorylation of the associated MLC on Ser19 (monophosphorylation), or in some cases on both Thr18 and Ser19 (diphosphorylation)|We detected Ser19 of MLC as the common phosphorylation site for the catalytic domains of MRCK_/_, ROK_, MLCK and PAK_, but only ROK_ and CRIK are able to phosphorylate both Thr18 and Ser19 residues causing diphosphorylation. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
KIF14 | up-regulates activity
binding
|
CIT |
0.713 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266422 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16431929 |
We find that KIF14 targets to the central spindle via its interaction with PRC1 and has an essential function in cytokinesis. In KIF14-depleted cells, citron kinase but not other components of the central spindle and cleavage furrow fail to localize. Furthermore, the localization of KIF14 and citron kinase to the central spindle and midbody is codependent, and they form a complex depending on the activation state of citron kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIT | up-regulates activity
binding
|
KIF14 |
0.713 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266424 |
|
|
Homo sapiens |
HEL Cell |
| pmid |
sentence |
| 16431929 |
We find that KIF14 targets to the central spindle via its interaction with PRC1 and has an essential function in cytokinesis. In KIF14-depleted cells, citron kinase but not other components of the central spindle and cleavage furrow fail to localize. Furthermore, the localization of KIF14 and citron kinase to the central spindle and midbody is codependent, and they form a complex depending on the activation state of citron kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CIT
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