Relation Results

Summary

Name CHD2
Full Name Chromodomain-helicase-DNA-binding protein 2
Synonyms CHD-2, ATP-dependent helicase CHD2 |
Primary ID O14647
Links - -
Type protein
Relations 5
Function DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of his ...
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Type: Score: Layout: SPV 
0.20.20.20.20.7CHD2H3-3AXRCC4PARP1MYOD1DNA_repair

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Relations
Regulator
Mechanism
target
score ℹ
+ CHD2up-regulates quantity img/direct-activation.png relocalization H3-3A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264527 Homo sapiens
pmid sentence
Non-homologous end-joining (NHEJ) is the dominant DSB repair pathway in human cells, but our understanding of how it operates in chromatin is limited. Here, we define a mechanism that plays a crucial role in regulating NHEJ in chromatin. This mechanism is initiated by DNA damage-associated poly(ADP-ribose) polymerase 1 (PARP1), which recruits the chromatin remodeler CHD2 through a poly(ADP-ribose)-binding domain. CHD2 in turn triggers rapid chromatin expansion and the deposition of histone variant H3.3 at sites of DNA damage.
Publications: 1 Organism: Homo Sapiens
+ CHD2up-regulates quantity img/direct-activation.png relocalization XRCC4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264528 Homo sapiens U2-OS Cell
pmid sentence
CHD2 Promotes the Recruitment of Core NHEJ Factors. overexpression of ATPase-dead CHD2 (K515R; Figure S5F), but not wild-type CHD2, also reduced the recruitment of XRCC4 (Figure 5E). Together, these findings suggest that the chromatin remodeling activity of CHD2 promotes the efficient assembly of NHEJ complexes at DSBs.
Publications: 1 Organism: Homo Sapiens
+ PARP1up-regulates quantity img/direct-activation.png binding CHD2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264526 Homo sapiens
pmid sentence
Non-homologous end-joining (NHEJ) is the dominant DSB repair pathway in human cells, but our understanding of how it operates in chromatin is limited. Here, we define a mechanism that plays a crucial role in regulating NHEJ in chromatin. This mechanism is initiated by DNA damage-associated poly(ADP-ribose) polymerase 1 (PARP1), which recruits the chromatin remodeler CHD2 through a poly(ADP-ribose)-binding domain. CHD2 in turn triggers rapid chromatin expansion and the deposition of histone variant H3.3 at sites of DNA damage.
Publications: 1 Organism: Homo Sapiens
+ CHD2up-regulates activity img/direct-activation.png binding MYOD1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264525
pmid sentence
CHD2 also showed an interaction with MyoD, a master regulator of skeletal muscle differentiation, and together MyoD and CHD2 bind to myogenic gene promoters.
Publications: 1
+ CHD2up-regulates img/indirect-activation.png DNA_repair 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264529 Mus musculus
pmid sentence
We show in mouse cells that the cNHEJ-dependent fusion of chromosomes containing uncapped telomeres requires the activity of CHD2. Together, these findings argue that the chromatin response mediated by CHD2 is triggered by the presence of DSBs and promotes repair of these lesions by the canonical KU-dependent NHEJ pathway.
Publications: 1 Organism: Mus Musculus
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