Summary

Name MYOD1
Full Name Myoblast determination protein 1
Synonyms Class C basic helix-loop-helix protein 1, bHLHc1, Myogenic factor 3, Myf-3 | BHLHC1, MYF3, MYOD
Primary ID P15172
Links - -
Type protein
Relations 106
Pathways Myofiber: hypertrophy_cAMP, Myogenesis modulation: DNA damage, Myoblast: IL6 and hypertrophy, Myostatin, NOTCH Signaling, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Pericyte: Myogenic transcriptional cascade, Pericyte: Prostaglandins and myogenesis, Rhabdomyosarcoma, Satellite: Calcium&myogenesis, Satellite: Dystrophin glycoprotein complex regulation, Satellite: FST transcriptional regulation, Satellite: IFN gamma, Satellite: IL1 , Satellite: IL6, Satellite: Myogenic transcriptional cascade, Satellite: NOTCH, Satellite: TNFA, Satellite: WNT, Satellite: DDR inhibition, Satellite: Myostatin, Satellite: miRNA network, Satellite: Prostaglandins and myogenesis, WNT Signaling and Myogenesis
Function Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation MYOD1 0.542
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation MYOD1 0.327
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MYOD1 0.374
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MYOD1 0.542
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MYOD1 0.371
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation MYOD1 0.292
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding SMARCA4 0.548
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding MYOD/E12E47 0.797
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates img/direct-activation.png MYOD1 0.269
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.278
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.27
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding MYOD1 0.623
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MYOD1 0.333
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png acetylation MYOD1 0.596
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.54
Publications: 1 Organism: Mus Musculus
Pathways:Rhabdomyosarcoma
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation VEGFA 0.406
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:NOTCH Signaling
+ up-regulates img/direct-activation.png acetylation, binding MYOD1 0.63
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation MYOD1 0.433
Publications: 1 Organism: Homo Sapiens
Tissue: C2C12 Cell
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ up-regulates img/indirect-activation.png MYOD1 0.446
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png transcriptional regulation MYOD1 0.3
Publications: 1 Organism: Mus Musculus
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ up-regulates img/indirect-activation.png MYOD1 0.302
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOG 0.432
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma
+ up-regulates activity img/indirect-activation.png MYOD1 0.33
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:WNT Signaling and Myogenesis
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination, binding MYOD1 0.582
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png binding, acetylation MYOD1 0.629
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates activity img/direct_inhibition.png MYOD1 0.603
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ITGA7 0.293
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png CDKN1A 0.417
Publications: 1 Organism: Mus Musculus
Pathways:Rhabdomyosarcoma
+ up-regulates quantity img/direct-activation.png transcriptional regulation PJA1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding MYOD1 0.373
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYOD1 0.25
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png transcriptional regulation CDKN1A 0.417
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates activity img/indirect-activation.png MYOD1 0.459
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png acetylation MYOD1 0.665
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ down-regulates quantity by destabilization img/indirect_inhibition.png MYOD1 0.624
Publications: 1 Organism: Mus Musculus
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MYOD1 0.529
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MYOD1 0.405
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis, Rhabdomyosarcoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.501
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma, WNT Signaling and Myogenesis
+ down-regulates img/indirect_inhibition.png MYOD1 0.354
Publications: 1
+ up-regulates activity img/indirect-activation.png MYOD1 0.359
Publications: 2 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
Pathways:WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding MYOD1 0.392
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MYOD1 0.568
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png binding MYOD1 0.483
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding MYOD1 0.282
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MYOD1 0.733
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding MYOD1 0.531
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation SP1 0.383
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.35
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/indirect-activation.png MYOD1 0.321
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding MYOD1 0.733
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IGF and Myogenesis, P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding MYOD1 0.448
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis, Rhabdomyosarcoma
+ form complex img/form-complex.png binding MYOD/HEB 0.657
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png post transcriptional regulation MYOD1 0.299
Publications: 1
+ down-regulates img/direct_inhibition.png deacetylation MYOD1 0.386
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYOG 0.432
Publications: 2
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma
+ up-regulates img/indirect-activation.png Differentiation 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:NOTCH Signaling
+ up-regulates activity img/direct-activation.png binding MYOD1 0.422
Publications: 2 Organism: , Homo Sapiens
Tissue: Muscle
Pathways:Rhabdomyosarcoma, WNT Signaling and Myogenesis
+ form complex img/form-complex.png binding MYOD1/SWI/SNF complex 0.422
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding MYOD1 0.422
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png binding SMARCD3 0.56
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding MYOD1 0.319
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png binding MYOD1 0.56
Publications: 1 Organism: In Vitro
Pathways:P38 Signaling and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CCND3 0.388
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.624
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma
+ form complex img/form-complex.png binding MYOD/E2-2 0.686
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MYOD1 0.719
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.476
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:WNT Signaling and Myogenesis
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation MYOD1 0.38
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination MYOD1 0.292
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation DES 0.243
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding MYOD1 0.373
Publications: 1 Organism: Mus Musculus
Tissue: Muscle
+ up-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma, WNT Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYH7 0.402
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding MYOD1 0.797
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding MYOD1 0.561
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MYOD1 0.443
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates img/direct_inhibition.png MYOD1 0.286
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.455
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding MYOD1 0.2
Publications: 1
+ up-regulates img/indirect-activation.png MYOD1 0.27
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates img/direct-activation.png binding MYOD1 0.432
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.269
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png transcriptional regulation MYOD1 0.623
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MYOD1 0.516
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.401
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png binding SWI/SNF complex 0.344
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png binding MYOD1 0.493
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png MYOD1 0.297
Publications: 1 Organism: Homo Sapiens
Tissue: Myotube
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDKN1A 0.417
Publications: 1 Organism: Mus Musculus
Pathways:Rhabdomyosarcoma
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MYOD1 0.3
Publications: 1 Organism: Mus Musculus
Tissue: Muscle
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FST 0.403
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation RB1 0.405
Publications: 1 Organism: Mus Musculus
Pathways:IGF and Myogenesis, Rhabdomyosarcoma