4.0
Summary
| Name |  PTGES
|
| Full Name | Prostaglandin E synthase |
| Synonyms | Microsomal glutathione S-transferase 1-like 1, MGST1-L1, Microsomal prostaglandin E synthase 1, MPGES-1, p53-induced gene 12 protein | MGST1L1, MPGES1, PGES, PIG12 |
| Primary ID | O14684 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Pathways | GPCR_CRC |
| Function | Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:18682561, PubMed:10377395, PubMed:12672824, PubMed:12460774, PubMed:10869354, PubMed:12244105). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PTGES | up-regulates quantity 
chemical modification
|
prostaglandin E2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 2,5-dimethylcelecoxib | down-regulates activity 
post transcriptional regulation
|
PTGES | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EGR1 | up-regulates quantity by expression 
transcriptional regulation
|
PTGES | 0.337 |
| Publications: | 1 | Organism: | Homo Sapiens | |