| + |
PEG3 | down-regulates quantity by repression 
transcriptional regulation
|
WNT9A |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282742 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23078764 |
Initially, we identified and characterized a subset of PEG3’s target genes and their DNA-binding motif. PEG3 was also shown to regulate the expression of Pgm2l1 through the binding of the identified motif. A gene expression survey of the validated PEG3 bound genes (from Figure 1) demonstrated multiple responses in which gene expression was either reduced (Grb10, Mapk14, Nt5c1a, Ppargc1b, Setd1a, Syap1, Wnt9a), increased (Dusp1, Pgm2l1), or remained the same (Aebp2, Eml2, Ndufs8, Sdhb). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
WNT9A | up-regulates 
binding
|
FZD3 |
0.638 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132070 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT9A | up-regulates
binding
|
CHRNA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195972 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22309736 |
We identified five wnts (wnt9a, wnt9b, wnt10b, wnt11, and wnt16) that are able to stimulate achr clustering, of which wnt9a and wnt11 are expressed abundantly in developing muscles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
WNT9A | up-regulates
binding
|
MUSK |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195975 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22309736 |
we provide evidence that wnt9a and wnt11 bind directly to the extracellular domain of musk, to induce musk dimerization and subsequent tyrosine phosphorylation of the kinase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
WNT9A | up-regulates
binding
|
LRP6 |
0.657 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132076 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT9A | up-regulates
binding
|
LRP5 |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132073 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
WNT9A
- 
- 