Summary

Name LRP5
Full Name Low-density lipoprotein receptor-related protein 5
Synonyms LRP-5 | LR3, LRP7
Primary ID O75197
Links - -
Type protein
Relations 26
Pathways Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis
Function Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins (PubMed:11336703, PubMed:11448771, PubMed:15778503, PubMed:11719191, PubMed:15908424, PubMed:16252235). Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11336703, PubMed:11719191). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11719191). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (PubMed:11336703, PubMed:25920554, PubMed:24706814, PubMed:14731402). Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development (PubMed:27228167, PubMed:16252235). Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png relocalization GSK3B/Axin/APC 0.672
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding LRP5 0.619
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP5 0.69
Publications: 2 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding LRP5 0.675
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP5 0.61
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP5 0.582
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP5 0.636
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL1 0.676
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding LRP5 0.587
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding LRP5 0.567
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP5 0.585
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP5 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding LRP5 0.584
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP5 0.578
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP5 0.655
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding LPR5/6 0.375
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP5 0.694
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP5 0.645
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP5 0.716
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP5 0.66
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP5 0.593
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP5 0.78
Publications: 2 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates quantity img/direct_inhibition.png relocalization AXIN1 0.825
Publications: 1 Organism: Mus Musculus