Summary

Name WNT9B
Full Name Protein Wnt-9b
Synonyms Protein Wnt-14b, Protein Wnt-15 | WNT14B, WNT15, WNT14B, WNT15
Primary ID O14905
Links - -
Type protein
Relations 5
Function Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding FZD3 0.607
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP6 0.615
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png WNT9B 0.28
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding LRP5 0.592
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CHRNA1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle