| + |
SOSTDC1 | down-regulates activity 
|
BMP7 |
0.761 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242752 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18032587 |
SOSTDC1 is orthologous to a recently characterized murine antagonist of BMPs-2, -4, and -7 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
WNT10A |
0.338 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242695 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
WNT5A |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242736 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
WNT7A |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242710 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
BMP2 |
0.582 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242746 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18032587 |
SOSTDC1 is orthologous to a recently characterized murine antagonist of BMPs-2, -4, and -7 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
WNT2B |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242701 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
WNT3A |
0.302 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242714 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 21113658 |
In this context, SOSTDC1 leads to decreased cellular proliferation and inhibition of Wnt3a- and BMP-7-induced signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOSTDC1 | down-regulates activity
|
WNT5B |
0.281 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242727 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIL3 | down-regulates quantity by repression
transcriptional regulation
|
SOSTDC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242767 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 25338303 |
E4BP4 is a repressor of epigenetically regulated SOSTDC1 expression in breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOSTDC1 | down-regulates activity
|
WNT11 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242721 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
WNT7B |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242733 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
BMP4 |
0.684 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242749 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18032587 |
SOSTDC1 is orthologous to a recently characterized murine antagonist of BMPs-2, -4, and -7 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
WNT4 |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242707 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
WNT1 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242704 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
WNT3 |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242730 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
WNT9B |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242739 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
WNT10B |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242698 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
WNT16 |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242718 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
WNT2 |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242724 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
WNT8A |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242742 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 21113658 |
For example, SOSTDC1 decreases Wnt signaling by impeding the binding of Wnt8 to the LRP6 receptor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SOSTDC1
- 
- 