| + |
KIRREL3 | up-regulates activity 
binding
|
CASK |
0.448 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269078 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33853164 |
A Missense De Novo Variant in the CASK-interactor KIRREL3 Gene Leading to Neurodevelopmental Disorder with Mild Cerebellar Hypoplasia. KIRREL3 is a gene important for the central nervous system development-in particular for the process of neuronal migration, axonal fasciculation, and synaptogenesis-and colocalizes and cooperates in neurons with CASK gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Cerebellum |
| + |
APBA1 | up-regulates activity
binding
|
CASK |
0.857 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264041 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 11036064 |
Interaction with Munc18 increases Mint1 binding to CASK. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
CDK5 | up-regulates activity
phosphorylation
|
CASK |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280216 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18054859 |
Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK.|We found that Cdk5 phosphorylates and regulates CASK distribution to membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CASK | up-regulates
binding
|
TBR1 |
0.448 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266835 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10749215 |
Here we report that, through its guanylate kinase domain, CASK interacts with Tbr-1, a T-box transcription factor that is involved in forebrain development. CASK enters the nucleus and binds to a specific DNA sequence (the T-element) in a complex with Tbr-1. CASK acts as a coactivator of Tbr-1 to induce transcription of T-element containing genes, including reelin, a gene that is essential for cerebrocortical development. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
CASK | up-regulates 
|
Synaptic_vesicle_exocytosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278901 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16842202 |
The CASK-Mint1-Veli complex acts as an adaptor protein complex interacting with -neurexin, the current model proposes that the CASK- Mint1-Veli complex functions as a nucleation site for the assembly of proteins involved in synaptic junctions and synaptic vesicle exocytosis (Fig. 3a). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ID1 |
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4.0
CASK
- 
- 