Summary

Name TBR1
Full Name T-box brain protein 1
Synonyms T-brain-1, TBR-1, TES-56 |
Primary ID Q16650
Links - -
Type protein
Relations 4
Function Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:25232744, PubMed:30250039). As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding FOXP2 0.579
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation AUTS2 0.372
Publications: 1 Organism: Mus Musculus
Tissue: Brain
+ up-regulates img/direct-activation.png binding TBR1 0.474
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation FEZF2 0.509
Publications: 1