| + |
CASK | up-regulates 
|
Exocytosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264044 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11036064 |
As neurexins have been proposed to function in neuronal cell adhesion, it is possible that they define specific sites at the plasma membrane and that Mint complexes and Mint1-CASK complexes on neurexin are involved in the localized recruitment of Munc18 to the sites of exocytosis. In support of this hypothesis, both CASK and Mint1 have been reported to be localized at synapses |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ID1 |
binding
|
CASK |
0.415 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-225149 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15694377 |
We identified a novel CASK-interacting protein, inhibitor of differentiation 1 (Id1) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APBA1 | up-regulates activity 
binding
|
CASK |
0.846 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264041 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 11036064 |
Interaction with Munc18 increases Mint1 binding to CASK. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
KIRREL3 | up-regulates activity
binding
|
CASK |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269078 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33853164 |
A Missense De Novo Variant in the CASK-interactor KIRREL3 Gene Leading to Neurodevelopmental Disorder with Mild Cerebellar Hypoplasia. KIRREL3 is a gene important for the central nervous system development-in particular for the process of neuronal migration, axonal fasciculation, and synaptogenesis-and colocalizes and cooperates in neurons with CASK gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Cerebellum |
| + |
CASK | up-regulates
binding
|
TBR1 |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266835 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10749215 |
Here we report that, through its guanylate kinase domain, CASK interacts with Tbr-1, a T-box transcription factor that is involved in forebrain development. CASK enters the nucleus and binds to a specific DNA sequence (the T-element) in a complex with Tbr-1. CASK acts as a coactivator of Tbr-1 to induce transcription of T-element containing genes, including reelin, a gene that is essential for cerebrocortical development. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
CASK
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