| Synonyms |
VLACS, VLCS, Arachidonate--CoA ligase, 6.2.1.15, Fatty acid transport protein 2, FATP-2, Fatty-acid-coenzyme A ligase, very long-chain 1, Long-chain-fatty-acid--CoA ligase, 6.2.1.3, Phytanate--CoA ligase, 6.2.1.24, Solute carrier family 27 member 2, THCA-CoA ligase, 6.2.1.7, Very long-chain-fatty-acid-CoA ligase | ACSVL1, FACVL1, FATP2, VLACS |
| Function |
Acyl CoA synthetase that activates long-chain and very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (PubMed:10198260, PubMed:10749848, PubMed:11980911). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260). Does not activate C24 bile acids, cholate and chenodeoxycholate (PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). Exhibits long-chain fatty acids (LCFA) transport activity and plays an important role in hepatic fatty acid uptake (PubMed:20530735). |
3.0
SLC27A2
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relocalization
