| + |
AKT | up-regulates activity 
phosphorylation
|
TBX3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244353 |
Ser719 |
AEKEAATsELQSIQR |
Homo sapiens |
|
| pmid |
sentence |
| 25595898 |
We have identified TBX3 as a key substrate of AKT3 in melanomagenesis. we have identified the AKT3 target site at serine residue 720 in the TBX3 protein and show that this site is phosphorylated in vivo. the phosphorylation at S720 promotes TBX3 protein stability, nuclear localization, transcriptional repression of E-cadherin, and its role in cell migration and invasion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT3 | up-regulates activity
phosphorylation
|
TBX3 |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-223534 |
Ser719 |
AEKEAATsELQSIQR |
Homo sapiens |
|
| pmid |
sentence |
| 25595898 |
We have identified TBX3 as a key substrate of AKT3 in melanomagenesis. we have identified the AKT3 target site at serine residue 720 in the TBX3 protein and show that this site is phosphorylated in vivo. the phosphorylation at S720 promotes TBX3 protein stability, nuclear localization, transcriptional repression of E-cadherin, and its role in cell migration and invasion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBX3 | down-regulates quantity by repression 
transcriptional regulation
|
CDH1 |
0.421 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-223537 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25595898 |
AKT phosphorylation potentiates the ability of TBX3 to repress the transcription of the E-cadherin gene |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBX3 | down-regulates quantity by repression 
transcriptional regulation
|
CDKN2A |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249603 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25211658 |
TBX2 and TBX3 function as transcriptional repressors and both have been shown to inhibit myogenesis (Carlson et al, 2002; Zhu et al, 2014). Abnormal expression of TBX2 has been reported in several cancers including breast, pancreas, and melanoma, where it has been shown to drive proliferation (reviewed in Abrahams et al (2010)). As has been previously shown in other cell types, TBX2 was found to induce a downregulation of p14/19ARF and function as a direct repressor of p21 in RMS |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBX3 | down-regulates quantity by repression
transcriptional regulation
|
CDKN1A |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249602 |
|
|
Homo sapiens |
Rhabdomyosarcoma Cell Line |
| pmid |
sentence |
| 25211658 |
TBX2 and TBX3 function as transcriptional repressors and both have been shown to inhibit myogenesis (Carlson et al, 2002; Zhu et al, 2014). Abnormal expression of TBX2 has been reported in several cancers including breast, pancreas, and melanoma, where it has been shown to drive proliferation (reviewed in Abrahams et al (2010)). As has been previously shown in other cell types, TBX2 was found to induce a downregulation of p14/19ARF and function as a direct repressor of p21 in RMS |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TBX3
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