+ |
AKT |
phosphorylation
|
FANCA |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251476 |
Ser1149 |
CLRSRDPsLMVDFIL |
in vitro |
|
pmid |
sentence |
11855836 |
FANCA is phosphorylated at Ser1149 by Akt. The biological significance of FANCA phosphorylation and its regulation by Akt remains unclear at this time. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
AKT1 |
phosphorylation
|
FANCA |
0.474 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252567 |
Ser1149 |
CLRSRDPsLMVDFIL |
in vitro |
|
pmid |
sentence |
11855836 |
FANCA is phosphorylated at Ser1149 by Akt. The biological significance of FANCA phosphorylation and its regulation by Akt remains unclear at this time. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
ATM | up-regulates
phosphorylation
|
FANCA |
0.423 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-182949 |
Ser1449 |
AAPDADLsQEPHLF |
Homo sapiens |
|
pmid |
sentence |
19109555 |
The s1449a mutant failed to completely correct a variety of fa-associated phenotypes. The dna damage response is coordinated by phosphorylation events initiated by apical kinases atm (ataxia telangectasia mutated) and atr (atm and rad3-related), and atr is essential for proper fa pathway function. Serine 1449 is in a consensus atm/atr site |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ATR | up-regulates
phosphorylation
|
FANCA |
0.576 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-182953 |
Ser1449 |
AAPDADLsQEPHLF |
Homo sapiens |
|
pmid |
sentence |
19109555 |
The s1449a mutant failed to completely correct a variety of fa-associated phenotypes. The dna damage response is coordinated by phosphorylation events initiated by apical kinases atm (ataxia telangectasia mutated) and atr (atm and rad3-related), and atr is essential for proper fa pathway function. Serine 1449 is in a consensus atm/atr site |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FANCA | form complex
binding
|
Fanconi anemia core complex |
0.95 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263240 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
17396147 |
This complex includes not only the five known FA proteins (FANC‐A, C, E, F, and G), but also four new polypeptides, which are named FAAPs for FANCA‐associated polypeptides. |Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
Publications: |
1 |
Organism: |
Homo Sapiens |