3.0
Summary
| Name |  ARPC5View Modifications |
| Full Name | Actin-related protein 2/3 complex subunit 5 |
| Synonyms | Arp2/3 complex 16 kDa subunit, p16-ARC | ARC16, ARC16 |
| Primary ID | O15511 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). |
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