4.0
Summary
| Name |  ARPC5View Modifications |
| Full Name | Actin-related protein 2/3 complex subunit 5 |
| Synonyms | Arp2/3 complex 16 kDa subunit, p16-ARC | ARC16, ARC16 |
| Primary ID | O15511 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPKAPK2 |
phosphorylation
|
ARPC5 | 0.351 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PRKCA | up-regulates activity 
phosphorylation
|
ARPC5 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARPC5 | form complex 
binding
|
ARP2/3 | 0.96 |
| Publications: | 1 | Organism: | Homo Sapiens | |