Summary

Name PHGDH
Full Name D-3-phosphoglycerate dehydrogenase
Synonyms 3-PGDH, 2-oxoglutarate reductase, 1.1.1.399, Malate dehydrogenase, 1.1.1.37 | PGDH3
Primary ID O43175
Links - -
Type protein
Relations 9
Function Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ PRKNdown-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PHGDH 0.2
Publications: 1 Organism: Homo Sapiens
+ SP1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PHGDH 0.2
Publications: 1 Organism: Homo Sapiens
+ HOXA10down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PHGDH 0.304
Publications: 1 Organism: Homo Sapiens
+ NFYCup-regulates quantity by expression img/indirect-activation.png transcriptional regulation PHGDH 0.2
Publications: 1 Organism: Homo Sapiens
+ PHGDHup-regulates activity img/direct-activation.png chemical modification 3-phosphonato-D-glycerate(3-) 0.8
Publications: 1 Organism: Homo Sapiens
+ PHGDHup-regulates activity img/direct-activation.png chemical modification 3-phosphonatooxypyruvate(3-) 0.8
Publications: 1 Organism: Homo Sapiens
+ NFYAup-regulates quantity by expression img/indirect-activation.png transcriptional regulation PHGDH 0.2
Publications: 1 Organism: Homo Sapiens
+ NFYBup-regulates quantity by expression img/indirect-activation.png transcriptional regulation PHGDH 0.2
Publications: 1 Organism: Homo Sapiens
+ PHGDHup-regulates activity img/direct-activation.png chemical modification (R)-2-hydroxyglutarate(2-) 0.8
Publications: 1