| + |
NFYC | up-regulates quantity by expression 
transcriptional regulation
|
GCH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252234 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15496512 |
Coactivator RNF4 is involved in the GCH gene expression. Through serial deletion and mutagenesis studies of the GCH promoter, we defined the RNF4-responsive element on GCH proximal promoter as a CCAAT box. RNF4 did not possess specific DNA binding activity toward this CCAAT box, which suggests that RNF4 may be a coactivator of the CCAAT boxbinding protein nuclear factor Y (NF-Y). RNF4 is a coactivator for nuclear factor Y on GTP cyclohydrolase I proximal promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFYC | up-regulates quantity by expression
transcriptional regulation
|
GFI1B |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254433 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19965638 |
HMGB2 binds to the GFI1B promoter in vivo and up-regulates its trans-activation most likely by enhancing the binding of Oct-1 and, to a lesser extent, of GATA-1 and NF-Y to the GFI1B promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFYC | up-regulates quantity by expression
transcriptional regulation
|
PHGDH |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255211 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18378410 |
Positive regulation of promoter activity of human 3-phosphoglycerate dehydrogenase (PHGDH) gene is mediated by transcription factors Sp1 and NF-Y. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFYC | form complex 
binding
|
NFY |
0.966 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-63019 |
|
|
Homo sapiens |
Macrophage, Monocyte |
| pmid |
sentence |
| 9885213 |
Nf-y is one of the best characterized ccaat binding proteins, and its unique structure and evolutionary conservation suggest that it plays a crucial role in transcription of eukaryotic genes.It Is a ubiquitous heteromeric transcription factor, composed of three subunits, nf-ya, nf-yb, and nf-yc, all necessary for dna binding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF4 | up-regulates activity 
binding
|
NFYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252231 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15496512 |
Coactivator RNF4 is involved in the GCH gene expression. Through serial deletion and mutagenesis studies of the GCH promoter, we defined the RNF4-responsive element on GCH proximal promoter as a CCAAT box. RNF4 did not possess specific DNA binding activity toward this CCAAT box, which suggests that RNF4 may be a coactivator of the CCAAT boxbinding protein nuclear factor Y (NF-Y). RNF4 is a coactivator for nuclear factor Y on GTP cyclohydrolase I proximal promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFYC | up-regulates quantity by expression
transcriptional regulation
|
SOX18 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254822 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18496767 |
co-transfection experiments revealed that over-expression of Sp3 and ZBP-89 down-regulate, while over-expression of NF-Y up-regulates SOX18 promoter activity in HeLa cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NFYC
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- 