| + |
CRX | down-regulates quantity by repression 
transcriptional regulation
|
RHO |
0.472 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253820 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15277472 |
KLF15 repressed transactivation of rhodopsin and IRBP promoters alone and in combination with the transcriptional activators Crx and/or Nrl. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRX | up-regulates quantity by expression 
transcriptional regulation
|
RS1 |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253822 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18927113 |
Our in vitro and in vivo results indicate that two CRE sites in the minimal RS1 promoter region control retinal RS1 expression and establish CRX as a key factor driving this expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRX | down-regulates quantity by repression
transcriptional regulation
|
RBP3 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253821 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15277472 |
KLF15 repressed transactivation of rhodopsin and IRBP promoters alone and in combination with the transcriptional activators Crx and/or Nrl. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FIZ1 | down-regulates activity 
binding
|
CRX |
0.457 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-223799 |
|
|
Bos taurus |
|
| pmid |
sentence |
| 12566383 |
Interaction of Fiz1 and NRL-leucine zipper was validated by GST pulldown assays and co-immunoprecipitation from bovine retinal nuclear extracts. Fiz1 suppressed NRL- but not CRX-mediated transactivation of rhodopsin promoter activity in transiently transfected CV1 cells. |
|
| Publications: |
1 |
Organism: |
Bos Taurus |
| + |
CRX | up-regulates quantity by expression
transcriptional regulation
|
RBP3 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254890 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10354480 |
OTX2, as well as CRX, a homeodomain protein very similar to OTX2, activates the human IRBP promoter in co-transfection experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATXN7 | down-regulates activity
binding
|
CRX |
0.607 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-223226 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11580893 |
We found that ataxin-7 and CRX colocalize and coimmunoprecipitate. We observed that polyglutamine-expanded ataxin-7 can dramatically suppress CRX transactivation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SP1 | up-regulates activity 
binding
|
CRX |
0.322 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-225336 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15781457 |
Zinc finger DNA-binding domains of both Sp1 and Sp3 interact with Crx. Sp4 and Sp1 produce much higher levels of transcriptional activation when co-transfected with Crx, they may additionally act by directly increasing the rate of transcriptional initiation by the general transcriptional apparatus through their activation domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP4 | up-regulates activity
binding
|
CRX |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-225333 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15781457 |
Sp4 directly binds Crx. Sp4 and Sp1 produce much higher levels of transcriptional activation when co-transfected with Crx, they may additionally act by directly increasing the rate of transcriptional initiation by the general transcriptional apparatus through their activation domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRX | up-regulates quantity by expression
transcriptional regulation
|
BEST1 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253815 |
|
|
in vitro |
|
| pmid |
sentence |
| 18849347 |
Three OTX family proteins - OTX1, OTX2 and CRX - bound to both Sites 1 and 2 in vitro, and all of them increased BEST1 promoter activity. |
|
| Publications: |
1 |
Organism: |
In Vitro |
4.0
CRX
- 
- 