Relation Results

Summary

Name SP4
Full Name Transcription factor Sp4
Synonyms SPR-1
Primary ID Q02446
Links - -
Type protein
Relations 3
Function Binds to GT and GC boxes promoters elements. Probable transcriptional activator.

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Type: Score: Layout: SPV 
0.20.20.389SP4RHOMAOBCRX

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Relations
Regulator
Mechanism
target
score ℹ
+ SP4up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RHO 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-225382 Homo sapiens HEK-293 Cell
pmid sentence
Sp4 and Sp1 are activators of the rod opsin promoter
Publications: 1 Organism: Homo Sapiens
+ SP4up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MAOB 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253869 Homo sapiens
pmid sentence
Cotransfection experiments show that Sp1 and its closely related family member Sp4 can trans-activate MAO B promoter activity through the proximal cluster of Sp1 sites and its activation can be repressed by the over-expression of Sp3 and a related family member BTEB2.
Publications: 1 Organism: Homo Sapiens
+ SP4up-regulates activity img/direct-activation.png binding CRX 0.389
Identifier Residue Sequence Organism Cell Line
SIGNOR-225333 Homo sapiens
pmid sentence
Sp4 directly binds Crx. Sp4 and Sp1 produce much higher levels of transcriptional activation when co-transfected with Crx, they may additionally act by directly increasing the rate of transcriptional initiation by the general transcriptional apparatus through their activation domains.
Publications: 1 Organism: Homo Sapiens
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