| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273854 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 35486320 |
Two additional proximal mediators were identified that are required for IL-1R–induced NF-κB activation: IRAK-2, a Pelle family member, and MyD88, a death domain–containing adapter molecule. IRAK-2 preferentially bound IL-1RI. A truncated version of IRAK-2 that lacked the first 96 amino acids [IRAK-2(97-590)] did not associate with IL-1RI, which suggests that the NH2-terminal segment docks with the cytoplasmic domain of IL-1RI. |
|
3.0
IRAK2
- 
- 
binding