| + |
IL1R1 | up-regulates activity 
binding
|
IL1RAP |
0.718 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251981 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10854325 |
Binding of IL-1 to its receptor results in rapid assembly of a membrane-proximal signalling complex that consists of two different receptor chains (IL-1Rs), IL-1RI and IL-1RAcP, the adaptor protein MyD88, the serine/threonine kinase IRAK and a new protein, which we have named Tollip. Here we show that, before IL-1β treatment, Tollip is present in a complex with IRAK, and that recruitment of Tollip–IRAK complexes to the activated receptor complex occurs through association of Tollip with IL-1RAcP. Co-recruited MyD88 then triggers IRAK autophosphorylation, which in turn leads to rapid dissociation of IRAK from Tollip (and IL-1Rs) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
| + |
IL1B | up-regulates activity
binding
|
IL1R1 |
0.903 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249511 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 24166242 |
Pro-IL-1beta, mIL-1beta and mIL-beta all bind to IL-1RI, which recruits the IL-1 receptor accessory protein (IL-1RAcP) as a co-receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling , SARS-CoV CYTOKINE STORM |
| + |
IL1R1 | up-regulates activity
phosphorylation
|
JNK |
0.389 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269883 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 9625767 |
Il-1 binding to its receptor triggers a cascade of signaling events, including activation of the stress-activated mitogen-activated protein (map) kinases, c-jun nh2-terminal kinase (jnk) and p38 map kinase, as well as transcription factor nuclear factor kappab (nf-kappab |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1RN | down-regulates activity 
binding
|
IL1R1 |
0.894 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262302 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2876877 |
Homozygous truncating mutations result in lack of secreted interleukin-1–receptor antagonist protein, which inhibits the proinflammatory cytokines interleukin-1α and interleukin-1β |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling , SARS-CoV CYTOKINE STORM |
| + |
IL1R1 | up-regulates activity
phosphorylation
|
MAPK10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249515 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 9625767 |
Il-1 binding to its receptor triggers a cascade of signaling events, including activation of the stress-activated mitogen-activated protein (map) kinases, c-jun nh2-terminal kinase (jnk) and p38 map kinase, as well as transcription factor nuclear factor kappab (nf-kappab |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1B | up-regulates
binding
|
IL1R1 |
0.903 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-58122 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9625767 |
Il-1 binding to its receptor triggers a cascade of signaling events, including activation of the stress-activated mitogen-activated protein (map) kinases, c-jun nh2-terminal kinase (jnk) and p38 map kinase, as well as transcription factor nuclear factor kappab (nf-kappab). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| Pathways: | IL1 Signaling , SARS-CoV CYTOKINE STORM |
| + |
IL1RAP | up-regulates
binding
|
IL1R1 |
0.718 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97396 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12530978 |
Here we report that the soluble form of the il-1 receptor accessory protein (acp) increases the affinity of binding of human il-1alpha and il-1beta to the soluble human type ii il-1 receptor by approximately 100-fold, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
| + |
IL1R1 | up-regulates 
|
Inflammation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171876 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21304099 |
The Il-1 family of ligands and receptors is primarily associated with acute and chronic inflammation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling , SARS-CoV CYTOKINE STORM |
| + |
IL1R1 | up-regulates activity
phosphorylation
|
MAPK8 |
0.389 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249513 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 9625767 |
Il-1 binding to its receptor triggers a cascade of signaling events, including activation of the stress-activated mitogen-activated protein (map) kinases, c-jun nh2-terminal kinase (jnk) and p38 map kinase, as well as transcription factor nuclear factor kappab (nf-kappab |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRAK2 | up-regulates activity
binding
|
IL1R1 |
0.685 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273854 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 35486320 |
Two additional proximal mediators were identified that are required for IL-1R–induced NF-κB activation: IRAK-2, a Pelle family member, and MyD88, a death domain–containing adapter molecule. IRAK-2 preferentially bound IL-1RI. A truncated version of IRAK-2 that lacked the first 96 amino acids [IRAK-2(97-590)] did not associate with IL-1RI, which suggests that the NH2-terminal segment docks with the cytoplasmic domain of IL-1RI. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1R1 | up-regulates activity
binding
|
MYD88 |
0.944 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67140 |
|
|
Homo sapiens |
EL-4 Cell |
| pmid |
sentence |
| 10217414 |
Interleukin-1 (il-1) stimulates the association of the il-1 receptor-associated protein kinase (irak) with the heterodimer of il-iri and il-iracp via the adapter protein myd88. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
| + |
IL1A | up-regulates activity
binding
|
IL1R1 |
0.759 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-35077 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 7964161 |
Interleukin-1 receptor (il-1r) is a cytokine receptor which binds interleukin 1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56718 |
|
|
Homo sapiens |
Brain Cancer Cell |
| pmid |
sentence |
| 9565970 |
Il-1ri is responsible for il-1 signaling |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
| + |
IL1R1 | up-regulates activity
phosphorylation
|
MAPK9 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249514 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 9625767 |
Il-1 binding to its receptor triggers a cascade of signaling events, including activation of the stress-activated mitogen-activated protein (map) kinases, c-jun nh2-terminal kinase (jnk) and p38 map kinase, as well as transcription factor nuclear factor kappab (nf-kappab |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1R1 | up-regulates activity
|
NfKb-p65/p50 |
0.507 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249512 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9625767 |
Il-1 binding to its receptor triggers a cascade of signaling events, including activation of the stress-activated mitogen-activated protein (map) kinases, c-jun nh2-terminal kinase (jnk) and p38 map kinase, as well as transcription factor nuclear factor kappab (nf-kappab) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling , SARS-CoV CYTOKINE STORM |
| + |
IL1R1 | up-regulates activity
|
IRAK1 |
0.912 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-119208 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14625308 |
Formation of the signaling il-1 receptor complex results in the activation and hyperphosphorylation of irak-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
3.0
IL1R1
- 
- 