3.0
Summary
| Name |  SRSF1View Modifications |
| Full Name | Serine/arginine-rich splicing factor 1 |
| Synonyms | Alternative-splicing factor 1, ASF-1, Splicing factor, arginine/serine-rich 1, pre-mRNA-splicing factor SF2, P33 subunit | ASF, SF2, SF2P33, SFRS1 |
| Primary ID | Q07955 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | up-regulates 
phosphorylation
|
SRSF1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DYRK1A |
phosphorylation
|
SRSF1 | 0.399 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||
| + | CLK3 | up-regulates activity
phosphorylation
|
SRSF1 | 0.545 |
| Publications: | 1 | Organism: | In Vitro | |
| + | SRSF1 | up-regulates 
|
Alternative_Splicing_Regulation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CLK1 | up-regulates activity
phosphorylation
|
SRSF1 | 0.695 |
| Publications: | 1 | Organism: | In Vitro | |
| + | SRP54 | up-regulates activity
binding
|
SRSF1 | 0.304 |
| Publications: | 1 | Organism: | In Vitro | |
| + | SRPK1 | up-regulates
phosphorylation
|
SRSF1 | 0.796 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CLK2 | up-regulates activity
phosphorylation
|
SRSF1 | 0.302 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CLK4 | up-regulates activity
phosphorylation
|
SRSF1 | 0.365 |
| Publications: | 1 | Organism: | In Vitro | |