| + |
MAPK14 | up-regulates 
phosphorylation
|
ZNHIT1 |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153899 |
Thr103 |
AEGPNYLtACAGPPS |
Homo sapiens |
|
| pmid |
sentence |
| 17380123 |
Our results indicate that p38 mapk plays an important role in the regulation of p18hamlet half?life. In particular, p38 mapk activation is required for the accumulation of p18hamlet induced by dna damage?inducing Agents such as uv. We also showed that several sites that are phosphorylated by p38? In vitro are also important for p18hamlet protein stability in cells. the high conservation of thr103 as a phosphorylation site in p18hamlet proteins from different species (figure 1a), together with the in vitro phosphorylation experiments, suggested that this residue could be an important target for p38 mapk |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165571 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20473270 |
We show that the srcap subunit named znhit1 or p18(hamlet), which is a substrate of p38 mapk, is recruited to the myogenin promoter at the onset of muscle differentiation, in a p38 mapk-dependent manner. Furthermore, p18hamlet was phosphorylated during myoblast differentiation in a p38 mapk-dependent manner (dal testo pmc) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ZNHIT1 | up-regulates quantity by expression
transcriptional regulation
|
MYOG |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165613 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20473270 |
We show that the srcap subunit named znhit1 or p18hamlet, which is a substrate of p38 mapk, is recruited to the myogenin promoter at the onset of muscle differentiation, in a p38 mapk-dependent manner. We also show that p18hamlet is required for h2a.z accumulation into this genomic region and for subsequent muscle gene transcriptional activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNHIT1 |
|
H2AZ1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165610 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20473270 |
The chromatin-remodelling complex snf2-related cbp activator protein (srcap) regulates chromatin structure in yeast by modulating the exchange of histone h2a for the h2a.z variant. We also show that p18hamlet is required for h2a.z accumulation into this genomic region and for subsequent muscle gene transcriptional activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
3.0
ZNHIT1
- 
- 