3.0
Summary
| Name |  H2AZ1View Modifications |
| Full Name | Histone H2A.Z |
| Synonyms | H2A/z | H2AZ |
| Primary ID | P0C0S5 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | DZIP3 | up-regulates activity 
monoubiquitination
|
H2AZ1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ZNHIT1 |
|
H2AZ1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Muscle | |||
| + | H2AZ1 | form complex 
binding
|
Nucleosome_H2A.Z.1 variant | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | SLBP | up-regulates quantity by expression
translation regulation
|
H2AZ1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |