Relation Results

Summary

Name MAP3K13
Full Name Mitogen-activated protein kinase kinase kinase 13
Synonyms Leucine zipper-bearing kinase, Mixed lineage kinase, MLK | LZK
Primary ID O43283
Links - -
Type protein
Relations 2
Function Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of ...
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Type: Score: Layout: SPV 
0.20.579MAP3K13TRIM25MAP2K7

Modifications Tables

Relations

Regulator
Mechanism
target
score
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TRIM25 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277456 Ser12 CPLAEELsCSICLEP Homo sapiens HEK-293T Cell
pmid sentence
Mechanistically, MAP3K13 phosphorylates the E3 ubiquitin ligase TRIM25 at Ser12 to decrease its polyubiquitination and proteasomal degradation.
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP2K7 0.579
Identifier Residue Sequence Organism Cell Line
SIGNOR-112349 Homo sapiens
pmid sentence
Lzk directly phosphorylated and activated mkk7.
Publications: 1 Organism: Homo Sapiens
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