Summary

Name PROM1
Full Name Prominin-1
Synonyms Antigen AC133, Prominin-like protein 1 | PROML1
Primary ID O43490
Links - -
Type protein
Relations 2
Function May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation PROM1 0.519
Publications: 2 Organism: Homo Sapiens