Relation Results

Summary

Name PTPRK
Full Name Receptor-type tyrosine-protein phosphatase kappa
Synonyms Protein-tyrosine phosphatase kappa, R-PTP-kappa | PTPK
Primary ID Q15262
Links - -
Type protein
Relations 5
Function Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signali ...
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Type: Score: Layout: SPV 
0.6010.3810.3610.2PTPRKEGFRSTAT3ZNRF3PROM1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PTPRK img/unknown.png dephosphorylation EGFR 0.601
Identifier Residue Sequence Organism Cell Line
SIGNOR-248722 Tyr1092 TFLPVPEyINQSVPK Cricetulus griseus CHO Cell
pmid sentence
RPTP-kappa also reduced epidermal growth factor-dependent EGFR tyrosine phosphorylation in CHO cells. Purified RPTP-kappa preferentially dephosphorylated EGFR tyrosines 1068 and 1173 in vitro.
Identifier Residue Sequence Organism Cell Line
SIGNOR-248723 Tyr1197 STAENAEyLRVAPQS Cricetulus griseus CHO Cell
pmid sentence
RPTP-kappa also reduced epidermal growth factor-dependent EGFR tyrosine phosphorylation in CHO cells. Purified RPTP-kappa preferentially dephosphorylated EGFR tyrosines 1068 and 1173 in vitro.
Publications: 2 Organism: Cricetulus Griseus
+ PTPRKdown-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.381
Identifier Residue Sequence Organism Cell Line
SIGNOR-277060 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
In this study, we investigated whether receptor-type tyrosine protein phosphatase kappa (PTPRK), the only protein tyrosine phosphatase at 6q that contains a STAT3 specifying motif, negatively regulates STAT3 activation in NKTCL.|Phosphatase substrate-trapping mutant assays demonstrated the binding of PTPRK to STAT3, and phosphatase assays showed that PTPRK directly dephosphorylated phospho-STAT3(Tyr705).
Publications: 1 Organism: Homo Sapiens
+ PTPRKup-regulates activity img/direct-activation.png dephosphorylation ZNRF3 0.361
Identifier Residue Sequence Organism Cell Line
SIGNOR-260110 Homo sapiens NCI-H1703 Cell
pmid sentence
We show that PTPRK acts via the transmembrane E3 ubiquitin ligase ZNRF3, a negative regulator of Wnt signaling promoting Wnt receptor degradation, which is also expressed in the organizer.
Publications: 1 Organism: Homo Sapiens
+ PTPRKdown-regulates activity img/direct_inhibition.png dephosphorylation PROM1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277133 in vitro
pmid sentence
PTPRK dephosphorylates CD133, which is a stem cell marker; phosphorylated CD133 accelerates xenograft tumor growth of colon cancer cells through the activation of AKT, but the functional significance of this has remained elusive.|Together, these observations suggest that PTPRK suppresses CD133\u2010mediated colon cancer growth both in\u00a0vitro and in\u00a0vivo.
Publications: 1 Organism: In Vitro
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