3.0
Summary
| Name |  VEGFD
|
| Full Name | Vascular endothelial growth factor D |
| Synonyms | VEGF-D, c-Fos-induced growth factor, FIGF | VEGFD |
| Primary ID | O43915 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Pathways | VEGF Signaling |
| Function | Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | VEGFD | up-regulates 
binding
|
FLT4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VEGFD | up-regulates 
|
Angiogenesis | 0.7 |
| Publications: | 1 | |||
| + | bevacizumab | down-regulates activity 
binding
|
VEGFD | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VEGFD | up-regulates
binding
|
KDR | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | VEGF Signaling | |||