Summary

Name FLT4
Full Name Vascular endothelial growth factor receptor 3
Synonyms VEGFR-3, Fms-like tyrosine kinase 4, FLT-4, Tyrosine-protein kinase receptor FLT4 | VEGFR3
Primary ID P35916
Links - -
Type protein
Relations 40
Inhibitors pazopanib; sunitinib; nintedanib; KRN-633; N-[[3-fluoro-4-[[2-(1-methyl-4-imidazolyl)-7-thieno[3,2-b]pyridinyl]oxy]anilino]-sulfanylidenemethyl]-2-phenylacetamide; regorafenib; axitinib; motesanib; Brivanib alaninate; 1-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-3-(5-methyl-3-isoxazolyl)urea; linifanib; lenvatinib; pazopanib hydrochloride; sorafenib tosylate; Telatinib
Function Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

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▶Modifications Tables

Relations


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Regulator Mechanism target score ℹ
+ SRCup-regulates img/direct-activation.png phosphorylation FLT4 0.533
Publications: 6 Organism: Homo Sapiens
+ FLT4up-regulates activity img/direct-activation.png phosphorylation FLT4 0.2
Publications: 6 Organism: Homo Sapiens
+ FLT4up-regulates activity img/direct-activation.png phosphorylation GLO1 0.2
Publications: 1 Organism: In Vitro
+ FLT4