Summary

Name EFNA2
Full Name Ephrin-A2
Synonyms EPH-related receptor tyrosine kinase ligand 6, LERK-6, HEK7 ligand, HEK7-L | EPLG6, LERK6
Primary ID O43921
Links - -
Type protein
Relations 6
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding EPHA4 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA5 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA7 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA8 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA6 0.14
Publications: 1 Organism: Homo Sapiens