Relation Results

Summary

Name EPHA7
Full Name Ephrin type-A receptor 7
Synonyms EPH homology kinase 3, EHK-3, EPH-like kinase 11, EK11, hEK11 | EHK3, HEK11
Primary ID Q15375
Links - -
Type protein
Relations 9
Function Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidir ...
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Type: Score: Layout: SPV 
0.4830.7980.2950.8050.7940.2740.20.2EPHA7EPHA10EFNA2HOXA13EFNA1EFNA3HOXD13GSCTOP2B

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Relations
Regulator
Mechanism
target
score ℹ
+ EPHA7up-regulates activity img/direct-activation.png phosphorylation EPHA10 0.483
Identifier Residue Sequence Organism Cell Line
SIGNOR-273873 Homo sapiens MCF-7 Cell
pmid sentence
By using co-immunoprecipitation, we demonstrated physical interaction between kinase-deficient EPHA10 with kinase-sufficient EPHA7 receptor. we speculate that the kinase activity of EPHA7 cross-phosphorylates EPHA10.
Publications: 1 Organism: Homo Sapiens
+ EFNA2up-regulates img/direct-activation.png binding EPHA7 0.798
Identifier Residue Sequence Organism Cell Line
SIGNOR-52206 Homo sapiens
pmid sentence
The activation of eph receptors by their ligands, which are membrane-anchored molecules, involves a cell-cell recognition event that often causes cell repulsion.
Publications: 1 Organism: Homo Sapiens
+ HOXA13up-regulates quantity by expression img/direct-activation.png transcriptional regulation EPHA7 0.295
Identifier Residue Sequence Organism Cell Line
SIGNOR-261631 Mus musculus NG-108-15 Cell
pmid sentence
Analysis of normalized luciferase expression confirmed that wt HOXA13 regulates gene expression through the EphA7 cis-regulatory DNA element
Publications: 1 Organism: Mus Musculus
+ EFNA1up-regulates img/direct-activation.png binding EPHA7 0.805
Identifier Residue Sequence Organism Cell Line
SIGNOR-56965 Homo sapiens
pmid sentence
The best known function is their role in the guidance of migration of axons and cells in the nervous system through repulsive interactions
Publications: 1 Organism: Homo Sapiens
+ EFNA3up-regulates img/direct-activation.png binding EPHA7 0.794
Identifier Residue Sequence Organism Cell Line
SIGNOR-52384 Homo sapiens
pmid sentence
The activation of eph receptors by their ligands, which are membrane-anchored molecules, involves a cell-cell recognition event that often causes cell repulsion
Publications: 1 Organism: Homo Sapiens
+ HOXA13up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EPHA7 0.295
Identifier Residue Sequence Organism Cell Line
SIGNOR-142428 Homo sapiens
pmid sentence
We show that hoxd13 andhoxa13activate transcription from the epha7 promoter and that a mutation of thehoxa13/hoxd13 binding site was sufficient to abolish activation.
Publications: 1 Organism: Homo Sapiens
+ HOXD13up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EPHA7 0.274
Identifier Residue Sequence Organism Cell Line
SIGNOR-142453 Homo sapiens
pmid sentence
We show that hoxd13 andhoxa13activate transcription from the epha7 promoter and that a mutation of thehoxa13/hoxd13 binding site was sufficient to abolish activation.
Publications: 1 Organism: Homo Sapiens
+ GSCdown-regulates quantity by repression img/direct_inhibition.png transcriptional regulation EPHA7 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261613 Mus musculus P-19 Cell
pmid sentence
We demonstrate that Goosecoid can act as a repressor of its own promoter activity in transient co-transfection experiments in mouse P19 cells and in Xenopus embryos. Autorepression depends on the presence of the homeodomain and is mediated through the prd element more proximal to the transcriptional start site.
Publications: 1 Organism: Mus Musculus
+ TOP2Bup-regulates quantity by expression img/indirect-activation.png transcriptional regulation EPHA7 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-242311 Homo sapiens
pmid sentence
While Top2a is essential in proliferating cells and has been linked to DNA replication and chromosome condensation/segregation, Top2b has been clearly indicated in regulating gene expression (e.g. Reln, Dab1, Catna2, Cdh13, Sst, Pbx3, and Epha7) during brain development
Publications: 1 Organism: Homo Sapiens
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