Relation Results

Summary

Name EPHA8
Full Name Ephrin type-A receptor 8
Synonyms EPH- and ELK-related kinase, EPH-like kinase 3, EK3, hEK3, Tyrosine-protein kinase receptor EEK | EEK, HEK3, KIAA1459
Primary ID P29322
Links - -
Type protein
Relations 10
Function Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidir ...
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Type: Score: Layout: SPV 
0.20.20.740.20.20.8120.810.74EPHA8NFIAEFNA2NFIBNFIXEFNA5EFNA1EFNA3

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ EPHA8up-regulates activity img/direct-activation.png phosphorylation EPHA8 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-251120 Tyr616 FYAEPHTyEEPGRAG Homo sapiens HEK-293 Cell
pmid sentence
Tyr-615 and Tyr-838 are major autophosphorylation sites of the EphA8 receptor. phosphorylation of Tyr-615 is critical for determining the association with Fyn whereas the integrity of Tyr-838 phosphorylation is required for efficient phosphorylation at Tyr-615 as well as other major sites.
Identifier Residue Sequence Organism Cell Line
SIGNOR-251121 Tyr839 LAYGERPyWNMTNRD Homo sapiens HEK-293 Cell
pmid sentence
Tyr-615 and Tyr-838 are major autophosphorylation sites of the EphA8 receptor. phosphorylation of Tyr-615 is critical for determining the association with Fyn whereas the integrity of Tyr-838 phosphorylation is required for efficient phosphorylation at Tyr-615 as well as other major sites.
Publications: 2 Organism: Homo Sapiens
+ NFIAup-regulates quantity img/direct-activation.png transcriptional regulation EPHA8 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268896 Mus musculus
pmid sentence
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8)
Publications: 1 Organism: Mus Musculus
+ EFNA2up-regulates img/direct-activation.png binding EPHA8 0.74
Identifier Residue Sequence Organism Cell Line
SIGNOR-52269 Homo sapiens
pmid sentence
The activation of eph receptors by their ligands, which are membrane-anchored molecules, involves a cell-cell recognition event that often causes cell repulsion. Therefore, eph receptors mediate signals that can override cell adhesion.
Publications: 1 Organism: Homo Sapiens
+ NFIBup-regulates quantity img/direct-activation.png transcriptional regulation EPHA8 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268903 Mus musculus
pmid sentence
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8)
Publications: 1 Organism: Mus Musculus
+ NFIXup-regulates quantity img/direct-activation.png transcriptional regulation EPHA8 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268910 Mus musculus
pmid sentence
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8)
Publications: 1 Organism: Mus Musculus
+ EFNA5up-regulates img/direct-activation.png binding EPHA8 0.812
Identifier Residue Sequence Organism Cell Line
SIGNOR-52479 Homo sapiens
pmid sentence
Efna5 are able to activate epha8
Publications: 1 Organism: Homo Sapiens
+ EFNA1up-regulates img/direct-activation.png binding EPHA8 0.81
Identifier Residue Sequence Organism Cell Line
SIGNOR-154298 Homo sapiens
pmid sentence
Ephrins are cell-surface tethered guidance cues that bind to eph receptor tyrosine kinases in trans on opposing cells.
Identifier Residue Sequence Organism Cell Line
SIGNOR-56968 Homo sapiens
pmid sentence
Ephrins are cell-surface tethered guidance cues that bind to eph receptor tyrosine kinases in trans on opposing cells.
Publications: 2 Organism: Homo Sapiens
+ EFNA3up-regulates img/direct-activation.png binding EPHA8 0.74
Identifier Residue Sequence Organism Cell Line
SIGNOR-52387 Homo sapiens
pmid sentence
Receptors of the epha group preferentially interact with glycosylphosphatidylinositol (gpi)-linked ligands (of the ephrin-a subclass, which comprises five ligands), while receptors of the ephb group preferentially interact with transmembrane ligands (of the ephrin-b subclass, which comprises three ligands) (table 1). In either case, binding of a ligand results in eph receptor autophosphorylation on tyrosine residues and activation of the kinase activity of the eph receptor
Publications: 1 Organism: Homo Sapiens
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