Summary

Name EIF4E2
Full Name Eukaryotic translation initiation factor 4E type 2
Synonyms eIF-4E type 2, eIF4E type 2, Eukaryotic translation initiation factor 4E homologous protein, Eukaryotic translation initiation factor 4E-like 3, eIF4E-like protein 4E-LP, mRNA cap-binding protein 4EHP, mRNA cap-binding protein type 3 | EIF4EL3
Primary ID O60573
Links - -
Type protein
Relations 3
Function Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:17368478, PubMed:25624349, PubMed:9582349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity). In P-bodies, component of a complex that promotes miRNA-mediated translational repression (PubMed:28487484).

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding EIF4E2/GIGYF1 complex 0.627
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination EIF4E2 0.665
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding EIF4E2/GIGYF2 complex 0.715
Publications: 1 Organism: Homo Sapiens