+ |
CHKA | down-regulates quantity by destabilization
phosphorylation
|
PLIN3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267650 |
Tyr251 |
ERLRQHAyEHSLGKL |
Homo sapiens |
Glioblastoma Cell |
pmid |
sentence |
34929314 |
In addition, as a protein kinase, CHKα2 phosphorylates PLIN2 at Tyrosine 232 and PLIN3 at Tyrosine 251. Phosphorylated PLIN2 and PLIN3 are separated from lipid droplets and degraded by Hsc70-mediated autophagy, thereby promoting lipid droplet lipolysis, fatty acid oxidation and glioblastoma growth |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PLIN3 | up-regulates activity
relocalization
|
M6PR |
0.72 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253093 |
|
|
Chlorocebus aethiops |
COS Cell |
pmid |
sentence |
9590177 |
TIP47 is present in cytosol and on endosomes and is required for MPR transport from endosomes to the trans-Golgi network in vitro and in vivo. TIP47 recognizes a phenylalanine/tryptophan signal in the tail of the cation-dependent MPR that is essential for its proper sorting within the endosomal pathway. These data suggest that TIP47 binds MPR cytoplasmic domains and facilitates their collection into transport vesicles destined for the Golgi. |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
+ |
RAB9A | up-regulates activity
|
PLIN3 |
0.573 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253089 |
|
|
|
|
pmid |
sentence |
18195106 |
Rab9-dependent transport from late endosomes to the Golgi requires the Rab9 effectors p40 (Diaz et al., 1997) and TIP47 (Diaz and Pfeffer, 1998), a protein that recognizes the cytoplasmic domains of the two types of MPRs and packages them into nascent transport vesicles (Carroll et al., 2001). MPR recycling also utilizes a TGN-localized coiled-coil protein named GCC185 that is also a Rab9 effector |
|
Publications: |
1 |
+ |
PLIN3 | up-regulates activity
relocalization
|
IGF2R |
0.715 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253092 |
|
|
Chlorocebus aethiops |
COS Cell |
pmid |
sentence |
9590177 |
TIP47 is present in cytosol and on endosomes and is required for MPR transport from endosomes to the trans-Golgi network in vitro and in vivo. TIP47 recognizes a phenylalanine/tryptophan signal in the tail of the cation-dependent MPR that is essential for its proper sorting within the endosomal pathway. These data suggest that TIP47 binds MPR cytoplasmic domains and facilitates their collection into transport vesicles destined for the Golgi. |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |