Summary

Name SLIT1
Full Name Slit homolog 1 protein
Synonyms Slit-1, Multiple epidermal growth factor-like domains protein 4, Multiple EGF-like domains protein 4 | KIAA0813, MEGF4, SLIL1
Primary ID O75093
Links - -
Type protein
Relations 5
Function Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.

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Relations

Regulator Mechanism target score ℹ
+ NFIXup-regulates quantity img/direct-activation.png transcriptional regulation SLIT1 0.2
Publications: 1 Organism: Mus Musculus
+ SLIT1up-regulates img/direct-activation.png binding GPC1 0.39
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ NFIAup-regulates quantity img/direct-activation.png transcriptional regulation SLIT1 0.26
Publications: 1 Organism: Mus Musculus
+ NFIBup-regulates quantity img/direct-activation.png transcriptional regulation SLIT1 0.252
Publications: 1 Organism: Mus Musculus
+ SLIT1up-regulates img/direct-activation.png binding ROBO 0.893
Publications: 1 Organism: Homo Sapiens