Relation Results

Summary

Name NFIA
Full Name Nuclear factor 1 A-type
Synonyms NF1-A, Nuclear factor 1/A, CCAAT-box-binding transcription factor, CTF, Nuclear factor I/A, NF-I/A, NFI-A, TGGCA-binding protein | KIAA1439
Primary ID Q12857
Links - -
Type protein
Relations 18
Function Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenov ...
View More

Viewer

Type: Score: Layout: SPV 
0.20.20.20.20.20.2590.20.20.20.2690.20.20.2480.20.20.20.2870.263NFIAETV5EPHA8FOXO6WNT5AGAS6SLIT1ANOS1MYOGEPHA4TFAP4ID3EPHA5MYOD1ROBO1NFIXNEUROD4NEUROD1RBFOX3

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ NFIAdown-regulates quantity img/direct_inhibition.png transcriptional regulation ETV5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268874 Mus musculus
pmid sentence
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development
Publications: 1 Organism: Mus Musculus
+ NFIAup-regulates quantity img/direct-activation.png transcriptional regulation EPHA8 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268896 Mus musculus
pmid sentence
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8)
Publications: 1 Organism: Mus Musculus
+ NFIAdown-regulates quantity img/direct_inhibition.png transcriptional regulation FOXO6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268875 Mus musculus
pmid sentence
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development
Publications: 1 Organism: Mus Musculus
+ NFIAdown-regulates quantity img/direct_inhibition.png transcriptional regulation WNT5A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268877 Mus musculus
pmid sentence
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development
Publications: 1 Organism: Mus Musculus
+ NFIAdown-regulates quantity img/direct_inhibition.png transcriptional regulation GAS6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268876 Mus musculus
pmid sentence
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development
Publications: 1 Organism: Mus Musculus
+ NFIAup-regulates quantity img/direct-activation.png transcriptional regulation SLIT1 0.259
Identifier Residue Sequence Organism Cell Line
SIGNOR-268892 Mus musculus
pmid sentence
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8)
Publications: 1 Organism: Mus Musculus
+ NFIAdown-regulates quantity img/direct_inhibition.png transcriptional regulation ANOS1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268872 Mus musculus
pmid sentence
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development
Publications: 1 Organism: Mus Musculus
+ NFIAup-regulates quantity by expression img/direct-activation.png transcriptional regulation MYOG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263983 Mus musculus
pmid sentence
NFIA binds to and activates the brown-fat-specific enhancers even before differentiation and later facilitates the binding of PPARgamma|NFIA has at least three functions on the transcriptional regulation of brown fat [2]. First, NFIA activates adipogenesis per se, through activating the transcription of Pparg, which encodes PPARgamma. Second, NFIA also activates the brown-fat-specific gene expression (such as Ucp1 and Ppargc1a) independent of the degree of adipocyte differentiation, through facilitating the binding of PPARgamma to the brown-fat-specific enhancers. Third, NFIA represses myogenesis through suppression of myogenic transcription factors such as Myod1 as well as Myog,
Publications: 1 Organism: Mus Musculus
+ NFIAup-regulates quantity img/direct-activation.png transcriptional regulation EPHA4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268894 Mus musculus
pmid sentence
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8)
Publications: 1 Organism: Mus Musculus
+ TFAP4up-regulates activity img/direct-activation.png binding NFIA 0.269
Identifier Residue Sequence Organism Cell Line
SIGNOR-226586 Homo sapiens HCT-116 Cell
pmid sentence
We also observed moderately increased recruitment of CTCF, HDAC1, and SP1 by the full-length AP-4 onto the WT DNA beads.
Publications: 1 Organism: Homo Sapiens
+ NFIAdown-regulates quantity img/direct_inhibition.png transcriptional regulation ID3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268873 Mus musculus
pmid sentence
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development
Publications: 1 Organism: Mus Musculus
+ NFIAup-regulates quantity img/direct-activation.png transcriptional regulation EPHA5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268895 Mus musculus
pmid sentence
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8)
Publications: 1 Organism: Mus Musculus
+ NFIAup-regulates quantity by expression img/direct-activation.png transcriptional regulation MYOD1 0.248
Identifier Residue Sequence Organism Cell Line
SIGNOR-263982 Mus musculus
pmid sentence
NFIA binds to and activates the brown-fat-specific enhancers even before differentiation and later facilitates the binding of PPARgamma|NFIA has at least three functions on the transcriptional regulation of brown fat [2]. First, NFIA activates adipogenesis per se, through activating the transcription of Pparg, which encodes PPARgamma. Second, NFIA also activates the brown-fat-specific gene expression (such as Ucp1 and Ppargc1a) independent of the degree of adipocyte differentiation, through facilitating the binding of PPARgamma to the brown-fat-specific enhancers. Third, NFIA represses myogenesis through suppression of myogenic transcription factors such as Myod1 as well as Myog,
Publications: 1 Organism: Mus Musculus
+ NFIAup-regulates quantity img/direct-activation.png transcriptional regulation ROBO1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268893 Mus musculus
pmid sentence
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8)
Publications: 1 Organism: Mus Musculus
+ NFIAup-regulates quantity img/direct-activation.png transcriptional regulation NFIX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268871 Mus musculus
pmid sentence
We report that, in the absence of Nfia or Nfib, there is a marked reduction in the spinal cord expression of NFIX, and that NFIB can transcriptionally activate Nfix expression in vitro. These data demonstrate that NFIX is part of the downstream transcriptional program through which NFIA and NFIB coordinate gliogenesis within the spinal cord.
Publications: 1 Organism: Mus Musculus
+ NFIAup-regulates quantity img/direct-activation.png transcriptional regulation NEUROD4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268891 Mus musculus
pmid sentence
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8)
Publications: 1 Organism: Mus Musculus
+ NFIAup-regulates quantity img/direct-activation.png transcriptional regulation NEUROD1 0.287
Identifier Residue Sequence Organism Cell Line
SIGNOR-268890 Mus musculus
pmid sentence
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8)
Publications: 1 Organism: Mus Musculus
+ NFIAup-regulates quantity img/direct-activation.png transcriptional regulation RBFOX3 0.263
Identifier Residue Sequence Organism Cell Line
SIGNOR-268911 Mus musculus
pmid sentence
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8)
Publications: 1 Organism: Mus Musculus
a simple tooltip