| + |
ROCK2 | up-regulates 
phosphorylation
|
IRF4 |
0.426 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167467 |
Ser447 |
YHRSIRHsSIQE |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 20697158 |
Carock2 phosphorylated irf4 at either of 2 distinct phosphorylation sites, s446 and s447 / rock2-mediated phosphorylation of irf4 regulated the synthesis of il-17 and il-21 and the differentiation of th17 cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167471 |
Ser448 |
HRSIRHSsIQE |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 20697158 |
Carock2 phosphorylated irf4 at either of 2 distinct phosphorylation sites, s446 and s447 / rock2-mediated phosphorylation of irf4 regulated the synthesis of il-17 and il-21 and the differentiation of th17 cells. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
IRF4 | down-regulates quantity by repression 
transcriptional regulation
|
CD68 |
0.302 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254284 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 12676954 |
However, our data show that PU.1/IRF-4 and IRF-8 heterocomplexes down-regulate CD68 promoter activity in macrophages and repression is dependent on the integrity of both the IRF and PU.1 half-sites of this composite element. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IRF4 | up-regulates 
|
M2_polarization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249543 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20729857 |
We found Irf4 to be one of the direct targets of Jmjd3-mediated demethylation. Finally, we found that Irf4 is a transcription factor crucial for the induction of M2 macrophage responses. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249559 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22378047 |
IL-4-induced c-Myc activity controls a subset of M2-associated genes. IL-4 also induces the M2-polarizing JMJD3-IRF4 axis to inhibit IRF5-mediated M1 polarization. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
IRF4 | down-regulates
|
M1_polarization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249561 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22378047 |
IL-4-induced c-Myc activity controls a subset of M2-associated genes. IL-4 also induces the M2-polarizing JMJD3-IRF4 axis to inhibit IRF5-mediated M1 polarization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
IRF4 | down-regulates activity 
|
IRF5 |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249560 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 22378047 |
IL-4-induced c-Myc activity controls a subset of M2-associated genes. IL-4 also induces the M2-polarizing JMJD3-IRF4 axis to inhibit IRF5-mediated M1 polarization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM6B | up-regulates quantity by expression
transcriptional regulation
|
IRF4 |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249540 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 22025054 |
JMJD3 seems to function by controlling expression of the transcription factor IRF4, which in turn is required for M2 polarization of macrophages in vitro and in vivo. Although this pathway is strongly supported by genetic. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
IRF4 | up-regulates quantity by expression
transcriptional regulation
|
FCER2 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253933 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11342629 |
IFN-regulatory factor 4 (IRF-4) plays a critical role in mature B cell function. Using the transcriptional regulation of the human B cell activation marker CD23 as a model system, we have previously demonstrated that IRF-4 is induced in response to B cell-activating stimuli and that it acts as a transactivator of CD23 gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF4 | up-regulates quantity by expression
transcriptional regulation
|
IL4 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254501 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 11956291 |
IRF4 synergizes with NFATc2 and the IL-4-inducing transcription factor, c-maf, to augment IL-4 promoter activity as well as to elicit significant levels of endogenous IL-4 production |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
3.0
IRF4
- 
- 