3.0
Summary
| Name |  IRF4View Modifications |
| Full Name | Interferon regulatory factor 4 |
| Synonyms | IRF-4, Lymphocyte-specific interferon regulatory factor, LSIRF, Multiple myeloma oncogene 1, NF-EM5 | MUM1 |
| Primary ID | Q15306 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Pathways | Macrophage polarization, Macrophage: IL4, T-Lymphocyte: IL4 and its transcriptional regulation |
| Function | Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ROCK2 | up-regulates 
phosphorylation
|
IRF4 | 0.428 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | KDM6B | up-regulates quantity by expression
transcriptional regulation
|
IRF4 | 0.435 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization | |||
| + | IRF4 | up-regulates quantity by expression 
transcriptional regulation
|
IL4 | 0.541 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization | |||
| + | IRF4 | down-regulates quantity by repression 
transcriptional regulation
|
CD68 | 0.303 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | IRF4 | up-regulates
|
M2_polarization | 0.7 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization | |||
| + | IRF4 | up-regulates quantity by expression
transcriptional regulation
|
FCER2 | 0.27 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IRF4 | down-regulates
|
M1_polarization | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Macrophage polarization | |||
| + | IRF4 | down-regulates activity 
|
IRF5 | 0.433 |
| Publications: | 1 | Organism: | Homo Sapiens | |