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Summary
| Name |  CLASP2View Modifications |
| Full Name | CLIP-associating protein 2 |
| Synonyms | Cytoplasmic linker-associated protein 2, Protein Orbit homolog 2, hOrbit2 | KIAA0627 |
| Primary ID | O75122 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PLK1 | up-regulates activity 
phosphorylation
|
CLASP2 | 0.622 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK1 | up-regulates activity
phosphorylation
|
CLASP2 | 0.569 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GSK3B | down-regulates activity 
phosphorylation
|
CLASP2 | 0.515 |
| Publications: | 2 | Organism: | Chlorocebus Aethiops | |
| + | CLASP2 | up-regulates activity
binding
|
CLIP1 | 0.771 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | ABL1 | up-regulates quantity
phosphorylation
|
CLASP2 | 0.502 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CLASP2 | up-regulates activity
binding
|
IQGAP1 | 0.416 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | CLASP2 | up-regulates activity
binding
|
MAPRE1 | 0.632 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | CLASP2 | up-regulates activity
binding
|
CLIP2 | 0.589 |
| Publications: | 1 | Organism: | Homo Sapiens | |