| + |
PRKCE | up-regulates 
phosphorylation
|
IQGAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133865 |
Ser1443 |
DKMKKSKsVKEDSNL |
Homo sapiens |
|
| pmid |
sentence |
| 15695813 |
Using a mass spectrometry-based assay, we show that egf induces phosphorylation of iqgap1 ser(1443), a residue known to be phosphorylated by pkcthe nonphosphorylatable iqgap1 s1441a/s1443a had no effect. In contrast, the s1441e/s1443d mutation markedly enhanced the ability of iqgap1 to induce neurite outgrowth. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-128718 |
Ser1443 |
DKMKKSKsVKEDSNL |
Homo sapiens |
|
| pmid |
sentence |
| 15355962 |
Using a mass spectrometry-based assay, we show that egf induces phosphorylation of iqgap1 ser(1443), a residue known to be phosphorylated by pkcthe nonphosphorylatable iqgap1 s1441a/s1443a had no effect. In contrast, the s1441e/s1443d mutation markedly enhanced the ability of iqgap1 to induce neurite outgrowth. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172239 |
Ser1443 |
DKMKKSKsVKEDSNL |
Homo sapiens |
|
| pmid |
sentence |
| 21349850 |
Using a mass spectrometry-based assay, we show that egf induces phosphorylation of iqgap1 ser(1443), a residue known to be phosphorylated by pkcthe nonphosphorylatable iqgap1 s1441a/s1443a had no effect. In contrast, the s1441e/s1443d mutation markedly enhanced the ability of iqgap1 to induce neurite outgrowth. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
PRKCA | up-regulates
phosphorylation
|
IQGAP1 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-128714 |
Ser1443 |
DKMKKSKsVKEDSNL |
Homo sapiens |
|
| pmid |
sentence |
| 15355962 |
Using a mass spectrometry-based assay, we show that egf induces phosphorylation of iqgap1 ser(1443), a residue known to be phosphorylated by pkcthe nonphosphorylatable iqgap1 s1441a/s1443a had no effect. In contrast, the s1441e/s1443d mutation markedly enhanced the ability of iqgap1 to induce neurite outgrowth. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172235 |
Ser1443 |
DKMKKSKsVKEDSNL |
Homo sapiens |
|
| pmid |
sentence |
| 21349850 |
Using a mass spectrometry-based assay, we show that egf induces phosphorylation of iqgap1 ser(1443), a residue known to be phosphorylated by pkcthe nonphosphorylatable iqgap1 s1441a/s1443a had no effect. In contrast, the s1441e/s1443d mutation markedly enhanced the ability of iqgap1 to induce neurite outgrowth. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133861 |
Ser1443 |
DKMKKSKsVKEDSNL |
Homo sapiens |
Breast Cancer Cell, Neuron |
| pmid |
sentence |
| 15695813 |
Using a mass spectrometry-based assay, we show that egf induces phosphorylation of iqgap1 ser(1443), a residue known to be phosphorylated by pkcthe nonphosphorylatable iqgap1 s1441a/s1443a had no effect. In contrast, the s1441e/s1443d mutation markedly enhanced the ability of iqgap1 to induce neurite outgrowth. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MAP4K3 | up-regulates activity
phosphorylation
|
IQGAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277479 |
Ser480 |
NTVWKQLsSSVTGLT |
in vitro |
|
| pmid |
sentence |
| 31431460 |
GLK directly phosphorylated IQGAP1 at Ser-480 enhancing Cdc42 activation and subsequent cell migration. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SRC | up-regulates activity
phosphorylation
|
IQGAP1 |
0.683 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277533 |
Tyr1510 |
LVKLQQTyAALNSKA |
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 33087447 |
IQGAP1 was phosphorylated exclusively on Tyr-1510 under conditions with enhanced MET or c-Src signaling, including in human lung cancer cell lines. This phosphorylation was significantly reduced by chemical inhibitors of MET or c-Src or by siRNA-mediated knockdown of MET. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MET | up-regulates activity
phosphorylation
|
IQGAP1 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277532 |
Tyr1510 |
LVKLQQTyAALNSKA |
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 33087447 |
IQGAP1 was phosphorylated exclusively on Tyr-1510 under conditions with enhanced MET or c-Src signaling, including in human lung cancer cell lines. This phosphorylation was significantly reduced by chemical inhibitors of MET or c-Src or by siRNA-mediated knockdown of MET. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IQGAP1 | down-regulates activity 
binding
|
RAC1 |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261889 |
|
|
|
|
| pmid |
sentence |
| 15695813 |
Although the name implies that it functions as a GTPase-activating protein, IQGAP1 actually stabilizes Cdc42 and Rac1 in the active, GTP-bound form (5, 8, 17). Thus, IQGAP1 acts as an “anti-GTPase-activating protein” for Cdc42 and Rac1, with marked effects on the cytoskeleton. |
|
| Publications: |
1 |
| + |
IQGAP1 | down-regulates activity
binding
|
CDC42 |
0.805 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261888 |
|
|
|
|
| pmid |
sentence |
| 15695813 |
Although the name implies that it functions as a GTPase-activating protein, IQGAP1 actually stabilizes Cdc42 and Rac1 in the active, GTP-bound form (5, 8, 17). Thus, IQGAP1 acts as an “anti-GTPase-activating protein” for Cdc42 and Rac1, with marked effects on the cytoskeleton. |
|
| Publications: |
1 |
| + |
CLASP2 | up-regulates activity
binding
|
IQGAP1 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264828 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 19638411 |
IQGAP1 is a novel CLASP2-interacting protein| nonphosphorylated CLASP2 on microtubules is allowed to associate with IQGAP1 for the coupling of microtubules to actin filaments at the front of migrating cells. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
NBEAL2 | down-regulates 
|
IQGAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261890 |
|
|
Mus musculus |
Blood Platelet |
| pmid |
sentence |
| 29187380 |
We found that the level of Iqgap1, a protein that stabilizes the active forms of Cdc42 and Rac1, was also significantly higher in Nbeal2−/− platelets |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
IQGAP1
- 
- 