| + |
MYT1L | up-regulates activity 
binding
|
SIN3B |
0.466 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266774 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 28379941 |
We found that the pan neuron-specific transcription factor Myt1-like (Myt1l) exerts its pro-neuronal function by direct repression of many different somatic lineage programs except the neuronal program. The repressive function of Myt1l is mediated via recruitment of a complex containing Sin3b by binding to a previously uncharacterized N-terminal domain. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SIN3B | form complex 
binding
|
Sin3B_complex |
0.755 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266967 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21041482 |
We report here the identification of a mammalian complex containing the corepressor Sin3B, the histone deacetylase HDAC1, Mrg15, and the PHD finger-containing Pf1 and show that this complex plays important roles in regulation of transcription. Sin3B, Pf1, Mrg15, and HDAC1 associate within a stable complex that binds H3K4me3/H3K36me3-enriched nucleosomes. We identify mammalian Pf1, a PHD finger protein, as a homologue of Rco1, and show that all four components, Sin3B, HDAC1, Mrg15, and Pf1, can form a stable complex, which is recruited downstream of the transcriptional start site through complex interactions with histones. these results indicate that the Pf1/Sin3B-containing complex is recruited at discrete sites within actively transcribed loci, likely through its interaction with H3K4me3/H3K36me3-enriched chromatin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF220 | down-regulates quantity by destabilization 
polyubiquitination
|
SIN3B |
0.441 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271943 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20170641 |
Here we identify RNF220 (RING finger protein 220) as a novel ubiquitin ligase for Sin3B. RNF220 specifically interacts with Sin3B both in vitro and in vivo. Sin3B can be regulated by the ubiquitin-proteasome system. Co-expression of RNF220 promotes the ubiquitination and proteasomal degradation of Sin3B. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIN3B | down-regulates activity
binding
|
TP53 |
0.515 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266776 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 26181367 |
The present study shows that under bleomycin-induced stress, expression of Sin3B gets up-regulated and it gets recruited by p53 at its target promoters. Knockdown of Sin3B leads to impaired negative regulation of p53 target genes and thus exemplifies Sin3B as a critical player in down-regulation of p53 subset target genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SIN3B
- 
- 