| + |
GADD45B | down-regulates activity 
binding
|
CDK11A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273024 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
Western blot analysis for SPDEF revealed that overexpression of GADD45α, β and γ prevents SPDEF degradation mediated by CDK11p58 |We identified CDK11p58 as an interaction partner of GADD45α by co-immunoprecipitation analysis. We corroborated these data by co-immunoprecipitation in vitro translation assays, showing that all three members of the GADD45 family interact with CDK11p58. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Integrator complex | down-regulates quantity by repression 
transcriptional regulation
|
GADD45B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261478 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25675981 |
The Integrator complex controls the termination of transcription at diverse classes of gene targets.|Following INTS3 or INTS9 knockdown, the levels of SDC4, JUNB, FOSL1, and GADD45B increased, suggesting that the Integrator complex negatively regulates the transcription of these genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates quantity by expression 
transcriptional regulation
|
GADD45B |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111963 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11713530 |
Here we report that nf-kappab complexes downregulate the c-jun amino-terminal kinase (jnk) cascade, thus establishing a link between the nf-kappab and the jnk pathways. This link involves the transcriptional upregulation of gadd45beta/myd118, which downregulates jnk induced by the tnf receptor (tnf-r). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GADD45B
- 
- 