Relation Results

Summary

Name BANF1
Full Name Barrier-to-autointegration factor
Synonyms Breakpoint cluster region protein 1 | BAF, BCRG1
Primary ID O75531
Links - -
Type protein
Relations 11
Function Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure ...
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Type: Score: Layout: SPV 
0.5070.20.8760.496VRK2BANF1PPP4CVRK1VRK3

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ VRK2down-regulates img/direct_inhibition.png phosphorylation BANF1 0.507
Identifier Residue Sequence Organism Cell Line
SIGNOR-143368 Ser4 sQKHRDFV Homo sapiens HeLa Cell
pmid sentence
We demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain. Coexpression of vrk1 and gfp-baf greatly diminishes the association of baf with the nuclear chromatin/matrix and leads to its dispersal throughout the cell
Identifier Residue Sequence Organism Cell Line
SIGNOR-144795 Ser4 sQKHRDFV Homo sapiens
pmid sentence
We demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain. Coexpression of vrk1 and gfp-baf greatly diminishes the association of baf with the nuclear chromatin/matrix and leads to its dispersal throughout the cell
Identifier Residue Sequence Organism Cell Line
SIGNOR-144799 Thr2 tTSQKHRD Homo sapiens
pmid sentence
Herein, we demonstrate that b1, vrk1, and vrk2 efficiently phosphorylate the extreme n' terminus of the baf protein. We demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain
Identifier Residue Sequence Organism Cell Line
SIGNOR-144803 Thr3 tSQKHRDF Homo sapiens
pmid sentence
We demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain. Coexpression of vrk1 and gfp-baf greatly diminishes the association of baf with the nuclear chromatin/matrix and leads to its dispersal throughout the cell
Publications: 4 Organism: Homo Sapiens
+ PPP4Cup-regulates img/direct-activation.png dephosphorylation BANF1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-144779 Ser4 sQKHRDFV Homo sapiens
pmid sentence
Herein, we demonstrate we demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain. We have identified the major phosphatase responsible for dephosphorylation of ser-4 to be protein phosphatase 4 catalytic subunit.
Identifier Residue Sequence Organism Cell Line
SIGNOR-203281 Ser4 sQKHRDFV Homo sapiens
pmid sentence
Herein, we demonstrate we demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain. We have identified the major phosphatase responsible for dephosphorylation of ser-4 to be protein phosphatase 4 catalytic subunit.
Publications: 2 Organism: Homo Sapiens
+ VRK1down-regulates img/direct_inhibition.png phosphorylation BANF1 0.876
Identifier Residue Sequence Organism Cell Line
SIGNOR-144783 Ser4 sQKHRDFV Homo sapiens
pmid sentence
We demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain. Coexpression of vrk1 and gfp-baf greatly diminishes the association of baf with the nuclear chromatin/matrix and leads to its dispersal throughout the cell
Identifier Residue Sequence Organism Cell Line
SIGNOR-143285 Ser4 sQKHRDFV Homo sapiens HeLa Cell
pmid sentence
We demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain. Coexpression of vrk1 and gfp-baf greatly diminishes the association of baf with the nuclear chromatin/matrix and leads to its dispersal throughout the cell
Identifier Residue Sequence Organism Cell Line
SIGNOR-144787 Thr2 tTSQKHRD Homo sapiens
pmid sentence
Herein, we demonstrate that b1, vrk1, and vrk2 efficiently phosphorylate the extreme n' terminus of the baf protein. We demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain
Identifier Residue Sequence Organism Cell Line
SIGNOR-144791 Thr3 tSQKHRDF Homo sapiens
pmid sentence
We demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain. Coexpression of vrk1 and gfp-baf greatly diminishes the association of baf with the nuclear chromatin/matrix and leads to its dispersal throughout the cell
Publications: 4 Organism: Homo Sapiens
+ VRK3down-regulates activity img/direct_inhibition.png phosphorylation BANF1 0.496
Identifier Residue Sequence Organism Cell Line
SIGNOR-264564 Ser4 sQKHRDFV in vitro
pmid sentence
Although VRK3 has been regarded as a genuine pseudokinase from structural and biochemical studies, recent reports suggest that VRK3 acts as an active kinase as well as a signaling scaffold in cells. Here, we demonstrate that VRK3 phosphorylates the nuclear envelope protein barrier-to-autointegration factor (BAF) on Ser4.|Ectopic expression of VRK3 induces the translocation of BAF from the nucleus to the cytoplasm. I
Publications: 1 Organism: In Vitro
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