Relation Results

Summary

Name PPP4C
Full Name Serine/threonine-protein phosphatase 4 catalytic subunit
Synonyms PP4C, Pp4, Protein phosphatase X, PP-X | PPP4, PPX
Primary ID P60510
Links - -
Type protein
Relations 12
Function Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, ...
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Type: Score: Layout: SPV 
0.4260.3640.20.3870.2440.4030.3680.4060.20.365PPP4CPLK1TP53BP1BANF1HDAC3ACACANDEL1RELACDK1PPP4R3ATRIM28

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PPP4Cdown-regulates activity img/direct_inhibition.png dephosphorylation PLK1 0.426
Identifier Residue Sequence Organism Cell Line
SIGNOR-277076 Ser137 LELCRRRsLLELHKR Homo sapiens
pmid sentence
PPP4C dephosphorylated PLK1 at the S137 site, negatively regulating its activity in the DSB response in early embryonic cells.
Publications: 1 Organism: Homo Sapiens
+ PPP4Cup-regulates activity img/direct-activation.png dephosphorylation TP53BP1 0.364
Identifier Residue Sequence Organism Cell Line
SIGNOR-264451 Ser1618 LTKAADIsLDNLVEG in vitro
pmid sentence
Here we show that 53BP1 is phosphorylated during mitosis on two residues, T1609 and S1618, located in its well-conserved ubiquitination-dependent recruitment (UDR) motif.|Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks |Depletion of PP4C, or PP4R3beta, causes persistence of phospho-T1609 and phospho-S1618
Identifier Residue Sequence Organism Cell Line
SIGNOR-264450 Thr1609 LGPYEAVtPLTKAAD in vitro
pmid sentence
Here we show that 53BP1 is phosphorylated during mitosis on two residues, T1609 and S1618, located in its well-conserved ubiquitination-dependent recruitment (UDR) motif.|Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks |Depletion of PP4C, or PP4R3beta, causes persistence of phospho-T1609 and phospho-S1618
Publications: 2 Organism: In Vitro
+ PPP4Cup-regulates img/direct-activation.png dephosphorylation BANF1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-203281 Ser4 sQKHRDFV Homo sapiens
pmid sentence
Herein, we demonstrate we demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain. We have identified the major phosphatase responsible for dephosphorylation of ser-4 to be protein phosphatase 4 catalytic subunit.
Identifier Residue Sequence Organism Cell Line
SIGNOR-144779 Ser4 sQKHRDFV Homo sapiens
pmid sentence
Herein, we demonstrate we demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain. We have identified the major phosphatase responsible for dephosphorylation of ser-4 to be protein phosphatase 4 catalytic subunit.
Publications: 2 Organism: Homo Sapiens
+ PPP4Cdown-regulates activity img/direct_inhibition.png dephosphorylation HDAC3 0.387
Identifier Residue Sequence Organism Cell Line
SIGNOR-248548 Ser424 DHDNDKEsDVEI Homo sapiens
pmid sentence
Here we demonstrate that, in addition to protein-protein interactions with NCoR/SMRT, the activity of HDAC3 is regulated by both phosphorylation and dephosphorylation. A protein kinase CK2 phosphoacceptor site in the HDAC3 protein was identified at position Ser424, which is a nonconserved residue among the class I HDACs. Mutation of this residue was found to reduce deacetylase activity.|Significantly, both overexpression and siRNA knock-down approaches, and analysis of cells devoid of PP4c, unequivocally show that HDAC3 activity is inversely proportional to the cellular abundance of PP4(c).
Publications: 1 Organism: Homo Sapiens
+ PPP4Cup-regulates activity img/direct-activation.png dephosphorylation ACACA 0.244
Identifier Residue Sequence Organism Cell Line
SIGNOR-267724 Ser80 LHIRSSMsGLHLVKQ Homo sapiens Hep-G2 Cell
pmid sentence
PP4 was also found to directly interact with pACC1‑Ser79 in human HepG2 cells. In conclusion, the present study showed that PP4 may be a novel regulator in hepatic lipogenesis through dephosphorylating ACC1 on serine 79, suggesting that PP4 may be a promising therapeutic target in lipid metabolism disorders.
Publications: 1 Organism: Homo Sapiens
+ PPP4Cdown-regulates activity img/direct_inhibition.png dephosphorylation NDEL1 0.403
Identifier Residue Sequence Organism Cell Line
SIGNOR-248550 Thr219 ASLSLPAtPVGKGTE Homo sapiens
pmid sentence
Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation|PP4c selectively dephosphorylates NDEL1 at Cdk1 sites. We also demonstrate that PP4c negatively regulates Cdk1 activity at the centrosome.|We next examined the ability of PP4c to dephosphorylate a Cdk1 phosphorylation site, phospho-T219
Publications: 1 Organism: Homo Sapiens
+ PPP4Cup-regulates activity img/direct-activation.png dephosphorylation RELA 0.368
Identifier Residue Sequence Organism Cell Line
SIGNOR-248549 Thr435 PTQAGEGtLSEALLQ Homo sapiens
pmid sentence
Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation
Publications: 1 Organism: Homo Sapiens
+ PPP4Cdown-regulates activity img/direct_inhibition.png dephosphorylation CDK1 0.406
Identifier Residue Sequence Organism Cell Line
SIGNOR-277162 Homo sapiens
pmid sentence
PP4c efficiently dephosphorylates Cdk1 sites of NDEL1 but does not dephosphorylate the Aurora A site.|We also found that PP4c negatively regulates Cdk1 activity in interphase.
Publications: 1 Organism: Homo Sapiens
+ PPP4R3Aup-regulates img/direct-activation.png binding PPP4C 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-180244 Homo sapiens
pmid sentence
Our data demonstrate that pp4r4 forms a novel cytosolic complex with pp4c, independent from the complexes containing pp4r1, pp4r2.PP4R3, and alpha4, and that the regulatory subunits of pp4c have evolved different modes of interaction with the catalytic subunit.
Publications: 1 Organism: Homo Sapiens
+ PPP4Cdown-regulates activity img/direct_inhibition.png dephosphorylation TRIM28 0.365
Identifier Residue Sequence Organism Cell Line
SIGNOR-277163 Homo sapiens
pmid sentence
PP4 dephosphorylated pKAP1 in vitro.
Publications: 1 Organism: Homo Sapiens
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