Summary

Name PPP4C
Full Name Serine/threonine-protein phosphatase 4 catalytic subunit
Synonyms PP4C, Pp4, Protein phosphatase X, PP-X | PPP4, PPX
Primary ID P60510
Links - -
Type protein
Relations 9
Function Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png dephosphorylation TP53BP1 0.363
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png dephosphorylation BANF1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation HDAC3 0.388
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation ACACA 0.246
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation NDEL1 0.397
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation RELA 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPP4C 0.2
Publications: 1 Organism: Homo Sapiens