| + |
CDK5/CDK5R1 | up-regulates activity 
phosphorylation
|
VRK3 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275545 |
Ser108 |
RPPTPKSsPQKTRKS |
|
|
| pmid |
sentence |
| 27346674 |
Vaccinia-related kinase 3 (VRK3), a member of the VRK family, is widely expressed in human tissues and increases VHR phosphatase activity through a direct binding|Here we report that oxidative stress-induced cyclin-dependent kinase 5 (CDK5) activation stimulates neuroprotective signaling via phosphorylation of vaccinia-related kinase 3 (VRK3) at Ser 108. The binding of vaccinia H1-related (VHR) phosphatase to phosphorylated VRK3 increased its affinity for phospho-ERK and subsequently downregulated ERK activation| |
|
| Publications: |
1 |
| + |
CDK5 | up-regulates activity
phosphorylation
|
VRK3 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275544 |
Ser108 |
RPPTPKSsPQKTRKS |
|
|
| pmid |
sentence |
| 27346674 |
Vaccinia-related kinase 3 (VRK3), a member of the VRK family, is widely expressed in human tissues and increases VHR phosphatase activity through a direct binding|Here we report that oxidative stress-induced cyclin-dependent kinase 5 (CDK5) activation stimulates neuroprotective signaling via phosphorylation of vaccinia-related kinase 3 (VRK3) at Ser 108. The binding of vaccinia H1-related (VHR) phosphatase to phosphorylated VRK3 increased its affinity for phospho-ERK and subsequently downregulated ERK activation| |
|
| Publications: |
1 |
| + |
VRK3 | down-regulates activity 
phosphorylation
|
BANF1 |
0.506 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264564 |
Ser4 |
sQKHRDFV |
in vitro |
|
| pmid |
sentence |
| 25899223 |
Although VRK3 has been regarded as a genuine pseudokinase from structural and biochemical studies, recent reports suggest that VRK3 acts as an active kinase as well as a signaling scaffold in cells. Here, we demonstrate that VRK3 phosphorylates the nuclear envelope protein barrier-to-autointegration factor (BAF) on Ser4.|Ectopic expression of VRK3 induces the translocation of BAF from the nucleus to the cytoplasm. I |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
VRK3 | up-regulates activity
binding
|
DUSP3 |
0.693 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275546 |
|
|
|
|
| pmid |
sentence |
| 27346674 |
Vaccinia-related kinase 3 (VRK3), a member of the VRK family, is widely expressed in human tissues and increases VHR phosphatase activity through a direct binding |
|
| Publications: |
1 |
3.0
VRK3
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