Summary

Name STAM2
Full Name Signal transducing adapter molecule 2
Synonyms STAM-2, Hrs-binding protein | HBP
Primary ID O75886
Links - -
Type protein
Relations 2
Function Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation STAM2 0.585
Publications: 1 Organism: In Vitro
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation STAM2 0.488
Publications: 1 Organism: Homo Sapiens