Summary

Name LTN1
Full Name E3 ubiquitin-protein ligase listerin
Synonyms RING finger protein 160, RING-type E3 ubiquitin transferase listerin, Zinc finger protein 294 | C21orf10, C21orf98, KIAA0714, RNF160, ZNF294
Primary ID O94822
Links - -
Type protein
Relations 2
Function E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875, PubMed:28757607). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination LTN1 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding RQC complex 0.511
Publications: 1