Relation Results

Summary

Name NFAT5
Full Name Nuclear factor of activated T-cells 5
Synonyms NF-AT5, T-cell transcription factor NFAT5, Tonicity-responsive enhancer-binding protein, TonE-binding protein, TonEBP | KIAA0827, TONEBP
Primary ID O94916
Links - -
Type protein
Relations 11
Function Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional ...
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Type: Score: Layout: SPV 
0.2740.20.20.20.350.360.490.335ATMNFAT5CSNK1A1LCDK1CDK5PTPN6RNA helicases DDX5/DDX17S100A4LCN2

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ ATMup-regulates img/direct-activation.png phosphorylation NFAT5 0.274
Identifier Residue Sequence Organism Cell Line
SIGNOR-125073 Ser1197 HIQTPMLsQEQAQPP Homo sapiens
pmid sentence
Tonebp/orebp contains atm consensus phosphorylation sites at ser-1197, ser-1247, and ser-1367. In conclusion, signaling via atm is necessary for full activation of tonebp/orebp
Identifier Residue Sequence Organism Cell Line
SIGNOR-125077 Ser1247 AMQSNSPsQEQQQQQ Homo sapiens
pmid sentence
Tonebp/orebp contains atm consensus phosphorylation sites at ser-1197, ser-1247, and ser-1367. In conclusion, signaling via atm is necessary for full activation of tonebp/orebp
Identifier Residue Sequence Organism Cell Line
SIGNOR-125081 Ser1367 LVQGSPSsQEQQVTL Homo sapiens
pmid sentence
Tonebp/orebp contains atm consensus phosphorylation sites at ser-1197, ser-1247, and ser-1367. In conclusion, signaling via atm is necessary for full activation of tonebp/orebp
Publications: 3 Organism: Homo Sapiens
+ CSNK1A1Lup-regulates activity img/direct-activation.png phosphorylation NFAT5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-274111 Ser158 LLDNSRMsCQDEGCG Homo sapiens HeLa Cell
pmid sentence
However, the siRNA knockdown of CK1α1L significantly reduced the nuclear export of OREBP/TonEBP under hypotonic conditions (Fig. 5F). Taken together, these data suggest that CK1α1L is the kinase that phosphorylates Ser-158 in the regulation of OREBP/TonEBP export.
Publications: 1 Organism: Homo Sapiens
+ CDK1up-regulates img/direct-activation.png phosphorylation NFAT5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-170882 Thr135 TVQQHPStPKRHTVL Homo sapiens HEK-293 Cell
pmid sentence
High nacl-induced activation of cdk5 increases phosphorylation of the osmoprotective transcription factor tonebp/orebp at threonine 135, which contributes to its rapid nuclear localization. we performed in vitro kinase assays using the tonebp/orebp peptide containing t135 as substrate (figure 3b, right panel) and various recombinant kinases. The peptide is strongly phosphorylated by cdk5, less by cdk1.
Publications: 1 Organism: Homo Sapiens
+ CDK5up-regulates img/direct-activation.png phosphorylation NFAT5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-170886 Thr135 TVQQHPStPKRHTVL Homo sapiens HEK-293 Cell
pmid sentence
High nacl-induced activation of cdk5 increases phosphorylation of the osmoprotective transcription factor tonebp/orebp at threonine 135, which contributes to its rapid nuclear localization. n hek293 cells, mass spectrometry shows phosphorylation of tonebp/orebp-s120, -s134, -t135, and -s155.
Publications: 1 Organism: Homo Sapiens
+ PTPN6down-regulates activity img/direct_inhibition.png dephosphorylation NFAT5 0.35
Identifier Residue Sequence Organism Cell Line
SIGNOR-248467 Tyr143 PKRHTVLyISPPPED Homo sapiens HEK-293 Cell
pmid sentence
We confirmed that SHP-1 is inhibitory by overexpressing it, which reduces TonEBP/OREBP transcriptional activity at 500 mosmol/kg. SHP-1 dephosphorylates TonEBP/OREBP at a known regulatory site, Y143, both in vivo and in vitro. It inhibits TonEBP/OREBP by both reducing TonEBP/OREBP nuclear localization, which is Y143 dependent, and by lowering high NaCl-induced TonEBP/OREBP transactivating activity
Publications: 1 Organism: Homo Sapiens
+ RNA helicases DDX5/DDX17up-regulates activity img/direct-activation.png binding NFAT5 0.36
Identifier Residue Sequence Organism Cell Line
SIGNOR-274112 Homo sapiens MDA-MB-231 Cell
pmid sentence
In this work, we report that ddx5 and ddx17 have a dual role in the control of the pro-migratory NFAT5 transcription factor. First, ddx5 and ddx17 act as transcriptional coactivators of NFAT5 and are required for activating NFAT5 target genes involved in tumor cell migration. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-274113 Homo sapiens MDA-MB-231 Cell
pmid sentence
In this work, we report that ddx5 and ddx17 have a dual role in the control of the pro-migratory NFAT5 transcription factor. First, ddx5 and ddx17 act as transcriptional coactivators of NFAT5 and are required for activating NFAT5 target genes involved in tumor cell migration. 
Publications: 2 Organism: Homo Sapiens
+ NFAT5up-regulates quantity by expression img/direct-activation.png transcriptional regulation S100A4 0.49
Identifier Residue Sequence Organism Cell Line
SIGNOR-274115 Homo sapiens MDA-MB-231 Cell
pmid sentence
 As expected, the depletion of NFAT5 decreased the S100A4 and LCN2 mRNA levels (Figure 3a). In addition, chromatin immunoprecipitation (ChIP) assay using NFAT5 antibody indicated that NFAT5 was bound to the S100A4 and LCN2 promoters (Figure 3b, Supplementary Figure S3), as expected (Chen et al., 2009).
Publications: 1 Organism: Homo Sapiens
+ NFAT5up-regulates quantity by expression img/direct-activation.png transcriptional regulation LCN2 0.335
Identifier Residue Sequence Organism Cell Line
SIGNOR-274114 Homo sapiens MDA-MB-231 Cell
pmid sentence
 As expected, the depletion of NFAT5 decreased the S100A4 and LCN2 mRNA levels (Figure 3a). In addition, chromatin immunoprecipitation (ChIP) assay using NFAT5 antibody indicated that NFAT5 was bound to the S100A4 and LCN2 promoters (Figure 3b, Supplementary Figure S3), as expected (Chen et al., 2009).
Publications: 1 Organism: Homo Sapiens
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