| + |
GLS | down-regulates quantity 
chemical modification
|
L-glutamine zwitterion |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260000 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22049910 |
Glutaminase (GLS1/2) catalyzes the conversion of L-glutamine to L-glutamate and ammonia. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glutamine metabolism |
| + |
miR-23b | down-regulates quantity
post transcriptional regulation
|
GLS |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255930 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21135128 |
MiR-130 reduces adipogenesis by repressing PPARγ biosynthesis and suggest that perturbations in this regulation is linked to human obesity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GLS | up-regulates activity 
|
Glutaminolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259999 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28053289 |
Glutaminase is the rate-limiting enzyme in glutaminolysis and it is encoded by two different genes, GLS and GLS2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
miR-23a | down-regulates quantity
post transcriptional regulation
|
GLS |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255929 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20060380 |
These results suggest that miR-27a would suppress adipocyte differentiation through targeting PPARgamma and thereby down-regulation of miR-27a might be associated with adipose tissue dysregulation in obesity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPARG | down-regulates quantity by repression 
transcriptional regulation
|
GLS |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268043 |
|
|
Homo sapiens |
Naive T-lymphocyte |
| pmid |
sentence |
| 33754076 |
Furthermore, the protein level of the rate-limiting enzyme GLS1 but not GLUD1, GOT1, or GPT2 was consistently reduced by PPARγ agonists |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT5 | up-regulates activity 
binding
|
GLS |
0.464 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261207 |
|
|
Homo sapiens |
HepG2-N10 Cell |
| pmid |
sentence |
| 30910998 |
Immunoprecipitation assays of interaction between GLS and SIRT5 in HepG2 cells infected with lentivirus containing empty or BAG3 construct. Ectopic BAG3 expression decreases the interaction between GLS and SIRT5. It has been reported that SIRT5 is responsible for desuccinylation of GLS35, immunoprecipitation (IP) was then performed. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GLS | up-regulates quantity
chemical modification
|
L-glutamate(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266910 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22049910 |
Glutaminase (GLS1/2) catalyzes the conversion of L-glutamine to L-glutamate and ammonia. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glutamine metabolism |
| + |
JUN | up-regulates quantity by expression
transcriptional regulation
|
GLS |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268035 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28111979 |
The transcription factor c-Jun can directly bind to the GLS gene promoter and enhance expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
GLS |
0.461 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268038 |
|
|
Homo sapiens |
B-lymphoma Cell Line |
| pmid |
sentence |
| 19219026 |
Here we report that the c-Myc (hereafter referred to as Myc) oncogenic transcription factor, which is known to regulate microRNAs and stimulate cell proliferation, transcriptionally represses miR-23a and miR-23b, resulting in greater expression of their target protein, mitochondrial glutaminase, in human P-493 B lymphoma cells and PC3 prostate cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GLS
- 
- 